Amy-Ray Winchester was used to weird crap happening. She came from a family of hunters and her older brother had kinda sorta accidentally started the apocalypse. Now Michael wanted to wear her older brother, Dean to the final showdown in Detroit while Lucifer dressed up as Sam.
Weird, Amy-Ray could handle. The Trickster turning out to be the archangel Gabriel who was claiming to be her soul mate? Yeah, that one's just batty.