Sheriff Matt Donovan is sick and tired of vampires taking over his town of Mystic Falls, Virginia, so when he is bitten one day by a wild wolf he gets the advantage. He soon becomes the predator that vampires are afraid of: a wolf. As one bite from a wolf can kill them.

Mark and Josie Johnson are newlyweds and go on their honeymoon to Cornwall, England. But what is supposed to be a honeymoon of heaven turns into a honeymoon from hell.