目前來說,mRNA武肺疫苗在應付疫情上擔當著不可或缺的角色。540Please respect copyright.PENANAEIflRKVWtE
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儘管如此, mRNA疫苗建立的初心,其實是在於對抗癌症方面之上,純粹是因為武肺爆發才出此變陣。540Please respect copyright.PENANA9H76VEcSQI
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(圖2)早在1990年,科學家已嘗試分別將mRNA及DNA注射到老鼠的肌肉裡頭,然後再切除部份肌肉來檢驗其注射效果。540Please respect copyright.PENANAZKvd2tLZY7
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(圖3)注射約18小時後,科學家透過檢驗肌肉裡頭的螢光表達量來推斷注射效果。540Please respect copyright.PENANAvhUqpHUp5p
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從圖中可見,若將mRNA或DNA的注射份量提升10倍,其螢光表達量亦會相繼提升10倍有多。540Please respect copyright.PENANAP71c4W5bBN
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這實驗的成功,亦因而奠定了日後mRNA疫苗的發展大方向。540Please respect copyright.PENANAhDxAJ5ZtCB
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下集我們將會講解 BioNTech究竟在mRNA疫苗上的設計做了甚麼的手腳,使之疫苗在免疫系統的觸發上取得重要的平衡。540Please respect copyright.PENANAlf4vShe8aL
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Ref1:https://science.sciencemag.org/content/247/4949/1465/tab-pdf540Please respect copyright.PENANAgzYXCaIj4S