現今科技發達,藥物大多數也能夠在實驗室或藥廠裡利用化學物合成出來。525Please respect copyright.PENANAwprSnuegWd
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但若果藥物主要成份的結構實在是太過複雜的話,有時候利用人工合成的方法製造只會吃力不討好,不符合經濟效益。525Please respect copyright.PENANAMS7sal62oC525Please respect copyright.PENANAuaJ582FHfy
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就以治療神經肌肉問題等疾病為例的Tropane alkaloids(TAs),主要情況下均是會從特定品種的植物裡頭提取出來;525Please respect copyright.PENANAoHKV28q3PS
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隸屬TAs類別的hyoscyamine及scopolamine可以與acetylcholine receptor結合,更有著解除俄國神經毒素Novichok的能力。525Please respect copyright.PENANADarlQLVjC9
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俄國神經毒素Novichok延伸閱讀:https://www.penana.com/article/477009525Please respect copyright.PENANAAuHFZCOTgg
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(圖2)科學家一直致力研究增強培植產生TAs植物的方法,但人口增長快速,相關藥物供不應求的問題開始湧現。525Please respect copyright.PENANAdJMleFz846525Please respect copyright.PENANAPeuahr4LwE
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再加上植物佔據大量空間及資源,而且生長需時,還有害蟲侵蝕植物導致產量下降各種問題需要關注,長遠來說顯然需要另一種手段製作藥物。525Please respect copyright.PENANAIAZo7eQ1PT
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(圖3)近日,有科學家發表文章(Ref1),利用生長快、易打理的酵母(yeast)來解決這問題。525Please respect copyright.PENANAbc1UFt3beZ
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他們利用CRISPR基因編輯技術,將26種來自細菌及植物的基因(其中一種更是燕麥的基因)加進酵母裡頭,強迫酵母利用葡萄糖及氨基酸轉化成為有用的TAs。525Please respect copyright.PENANAjqxb7dJqcJ525Please respect copyright.PENANA5zbFYyHX0W
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CRISPR基因編輯技術延伸閱讀:https://www.penana.com/article/465369525Please respect copyright.PENANANRweEcNyRt
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過程中他們更分門別類將相應的酵素安放在酵母各個位置,以及刪走一些礙事的基因,務求令到酵母一心一意為製作藥物為主。525Please respect copyright.PENANAG7afTGrcq5
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暫時他們做到的產量為每一公升酵母能夠生產出30-80 μg TAs,有望在1-2年後提升至每升5g,踏進真實市場裡頭運作。525Please respect copyright.PENANALqO8cFFCm0
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(1g=1000mg,1mg=1000 μg)525Please respect copyright.PENANA0AZJ9nWP4h
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。525Please respect copyright.PENANAe3wj9gPYji
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc525Please respect copyright.PENANAuBEtYmvu8u
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。525Please respect copyright.PENANAfL3RpwQOgY
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Link:525Please respect copyright.PENANAkuwy1v08Zs
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio525Please respect copyright.PENANAykob27LqIr
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。525Please respect copyright.PENANAe82nGNmpK7
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Ref1:https://www.nature.com/articles/s41586-020-2650-9525Please respect copyright.PENANAm3hSsFrvde