血糖高企是糖尿病其中之一的特徵。416Please respect copyright.PENANAcaAnHQM3Fn
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注射胰島素能加快身體細胞吸取血液糖份的速度,幫助降低血糖濃度,而前提當然是患者的身體細胞依然能對胰島素起上反應。416Please respect copyright.PENANApkvFrgC7Ds
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(圖2)常用的胰島素Glargine接近需要每日注射一次,有不少病人因嫌麻煩或其他原因沒能持之以恆注射,導致沒法完整地完成療程。416Please respect copyright.PENANAQdmiXoHmhl
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現今廠商開發了名為Icodec的胰島素,標榜只需一星期打一次,亦能達致體內胰島素每日平均的濃度與Glargine用家大致相同。416Please respect copyright.PENANACXnADuG0zc
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Icodec經過一系列的結構改造,使其能夠與血液含量豐富的白蛋白(Albumin)結合,416Please respect copyright.PENANAXsFISTSsW6
達致在血液中緩慢釋放胰島素到達細胞的效果。416Please respect copyright.PENANAgjRLV1tPE1
而且蛋白酶分解它的速度有所被調減,因此可以達致一劑過高濃度,而又能穩定地慢慢以低劑量的方式釋放到細胞裡頭。416Please respect copyright.PENANA6MW0kc9KFK
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(圖3)經過26星期的療程後,需要一日打一次的Glargine(122人)與只需一星期打一次的Icodec(125人)均能降低血糖濃度,而且兩者並無顯著的分別(Ref1)。416Please respect copyright.PENANAo4BWHdn2Sq
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若能招募更多人士確立其安全性及功效,只需一星期打一次的Icodec將來或許能打入市場,有助便利病人完成整個療程。416Please respect copyright.PENANAK1AtUe5yk6
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但這並不代表Glargine的市場會完全地被取締,當用家需要因每日所需調整胰島素濃度的話,Glargine始終是較佳的選擇。416Please respect copyright.PENANAqozNc3Uv5a
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Ref1: https://www.nejm.org/doi/10.1056/NEJMoa2022474