血糖高企是糖尿病其中之一的特徵。447Please respect copyright.PENANAmeiPBLBOnS
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注射胰島素能加快身體細胞吸取血液糖份的速度,幫助降低血糖濃度,而前提當然是患者的身體細胞依然能對胰島素起上反應。447Please respect copyright.PENANAdp71e1H8aa
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(圖2)常用的胰島素Glargine接近需要每日注射一次,有不少病人因嫌麻煩或其他原因沒能持之以恆注射,導致沒法完整地完成療程。447Please respect copyright.PENANAKMTkzomqX6
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現今廠商開發了名為Icodec的胰島素,標榜只需一星期打一次,亦能達致體內胰島素每日平均的濃度與Glargine用家大致相同。447Please respect copyright.PENANA9cL2BX7qzM
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Icodec經過一系列的結構改造,使其能夠與血液含量豐富的白蛋白(Albumin)結合,447Please respect copyright.PENANAKuuG546Bam
達致在血液中緩慢釋放胰島素到達細胞的效果。447Please respect copyright.PENANAjGT9jWybbc
而且蛋白酶分解它的速度有所被調減,因此可以達致一劑過高濃度,而又能穩定地慢慢以低劑量的方式釋放到細胞裡頭。447Please respect copyright.PENANAZCCAG4r4hv
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(圖3)經過26星期的療程後,需要一日打一次的Glargine(122人)與只需一星期打一次的Icodec(125人)均能降低血糖濃度,而且兩者並無顯著的分別(Ref1)。447Please respect copyright.PENANA2oPE1shke9
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若能招募更多人士確立其安全性及功效,只需一星期打一次的Icodec將來或許能打入市場,有助便利病人完成整個療程。447Please respect copyright.PENANAiHaEOgyPm3
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但這並不代表Glargine的市場會完全地被取締,當用家需要因每日所需調整胰島素濃度的話,Glargine始終是較佳的選擇。447Please respect copyright.PENANAWkx5CwBP4U
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Ref1: https://www.nejm.org/doi/10.1056/NEJMoa2022474