我們身體的各部份均是由細胞組成,眼睛晶片也自當然不例外。677Please respect copyright.PENANAcP6WQTWrgh
但細胞裡頭有著各式各樣的細胞器官,例如負責製造能源的粒線體(mitochondria)、收藏DNA的細胞核(nucleus)等,它們顯然並不是透明的。677Please respect copyright.PENANA6bhMELZeyG
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究竟身體有甚麼方法可以製造透明且能讓光線通過的眼鏡晶片呢?677Please respect copyright.PENANALMpXWwhLWt
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(圖2)答案很簡單,就是把那些細胞器官通通摧毀。677Please respect copyright.PENANA38xehcKPXZ
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從圖中可見,晶片的外圍有著表皮細胞(Epithelial cells)以及纖維細胞(Fibre cells),唯獨是中間區域的細胞,它們的細胞器官均接近得消失得一乾二淨。677Please respect copyright.PENANAgQ7yTwzzf6
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(圖3)有科學家利用班馬魚作動物模型,並將兩款細胞器官分別染成綠色及紅色。677Please respect copyright.PENANAvYiFnxL5wl
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從圖中可見,直至班馬魚受精後約59小時左右,綠色及紅色均分別清晰可見及有著其獨特的分佈,表示兩款細胞器官非常健在。677Please respect copyright.PENANA99kgTa2S7p
但在約60小時打後,紅色和綠色開始有著衰退的現象,亦即表示細胞器官開始逐漸被受摧毀。677Please respect copyright.PENANAJjfrKa3T6T
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(圖4)找出眼睛晶片的細胞器官被受摧毀的時段後,研究人員便著手進行一系列的實驗,677Please respect copyright.PENANA9OUJuEeKNr
並發現名為plaat的蛋白質負責在細胞器官的外膜進行破壞,因而引發細胞器官摧毀的過程。677Please respect copyright.PENANAQap1pPNNPc
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圖中為班馬魚的眼睛晶片,可見因為缺乏plaat蛋白質的緣故,細胞器官沒能完整摧毀,其晶片亦變得相對上混濁及不透光,影像亦較為不清晰。677Please respect copyright.PENANA1wAyB44tak
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(圖5)除班馬魚外,研究人員亦有利用老鼠進行實驗。677Please respect copyright.PENANADIeOpGD5Uy
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跟班馬魚一樣,缺乏plaat蛋白質的老鼠眼睛晶片變得混濁及不透光,並影響視線。677Please respect copyright.PENANARvoyAaaD5B
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。677Please respect copyright.PENANARgrlf1DAGx
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc677Please respect copyright.PENANAtwh1M1ZgSE
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。677Please respect copyright.PENANA8sfI0oraur
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Link:677Please respect copyright.PENANAj1sPrRvZxg
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio677Please respect copyright.PENANAfu3HohrSlB
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。677Please respect copyright.PENANAF6L33wIA42
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Ref1:https://www.nature.com/articles/s41586-021-03439-w677Please respect copyright.PENANAC7noeAazLY