國藥及科興是中國兩款滅活病毒疫苗。而科興數據其可信性之高,就連公開聲稱戴口罩便沒法說話的梁卓偉院長也怕怕唔敢打。465Please respect copyright.PENANA9EMP4l5pXQ
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大概是因為中國頭兩款疫苗過於「聲名大噪」,其第三款疫苗康希諾疫苗的關注度則相對較為低。而事實上,康希諾(Cansino)的疫苗設計其實是跟牛津疫苗非常相似。465Please respect copyright.PENANAkxYPwzgVsF
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(圖2)圖中為康希諾及牛津疫苗兩款疫苗的扼要原理。465Please respect copyright.PENANABRjOHTFeVc
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1.疫苗的主要成份為已被削弱複製能力且無害的病毒,內含武肺S蛋白的DNA資訊。465Please respect copyright.PENANAs71IL3I7Qw
2. 病毒進入人體細胞。465Please respect copyright.PENANAPrt4Swbd7k
3. 人體細胞利用病毒內含的武肺S蛋白DNA資訊,製作武肺S蛋白。465Please respect copyright.PENANApcY1P0S5G7
4.免疫系統的相關細胞辨認武肺S蛋白是為外來之物,因而製作相應的抗體。465Please respect copyright.PENANAM6J5uUEqUU
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(圖3)因為康希諾疫苗所用的是人類常見的感冒病毒,約4-6成的人早已擁有對抗這感冒病毒的抗體,因此病毒還沒能進入細胞之前(圖2的步驟2),便早已被自身的抗體攔截。465Please respect copyright.PENANApVDWNTcTBT
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而牛津所用的是黑猩猩所搵到的感冒病毒,原理上人體並沒有對應的抗體,因此亦相對上更易進入細胞。465Please respect copyright.PENANAFTPUSYAOsY
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以這方面來看,牛津疫苗的設計比康希諾技勝一籌。465Please respect copyright.PENANAgtB3M1l2Bc
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最近Bloomberg (Ref3)表示Cansino疫苗的保護效率達65.7%,而它跟Johnson&Johnson的疫苗一樣,均是一次性的方式注射。465Please respect copyright.PENANA9v30JcZptf
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延伸閱讀:465Please respect copyright.PENANASOiaylhLQ1
深入淺出–林鄭注射輝瑞/科興疫苗的最壞後果465Please respect copyright.PENANAQdcMZia49I
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Ref1:https://science.sciencemag.org/content/370/6522/1263465Please respect copyright.PENANAWlgpmJvBVb
Ref2:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067905/465Please respect copyright.PENANAUlV9xCtLhy
Ref3:https://www.bloomberg.com/news/articles/2021-02-08/pakistan-says-cansino-s-covid-vaccine-shows-65-7-efficacy465Please respect copyright.PENANACcCqNUPygz