國藥及科興是中國兩款滅活病毒疫苗。而科興數據其可信性之高,就連公開聲稱戴口罩便沒法說話的梁卓偉院長也怕怕唔敢打。477Please respect copyright.PENANApDJhlyM3u6
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大概是因為中國頭兩款疫苗過於「聲名大噪」,其第三款疫苗康希諾疫苗的關注度則相對較為低。而事實上,康希諾(Cansino)的疫苗設計其實是跟牛津疫苗非常相似。477Please respect copyright.PENANAWZPuLQtF1v
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(圖2)圖中為康希諾及牛津疫苗兩款疫苗的扼要原理。477Please respect copyright.PENANAMDMg78RGxb
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1.疫苗的主要成份為已被削弱複製能力且無害的病毒,內含武肺S蛋白的DNA資訊。477Please respect copyright.PENANANUm9hM6r9n
2. 病毒進入人體細胞。477Please respect copyright.PENANAxamrp1N1qQ
3. 人體細胞利用病毒內含的武肺S蛋白DNA資訊,製作武肺S蛋白。477Please respect copyright.PENANAIBrqWli3MF
4.免疫系統的相關細胞辨認武肺S蛋白是為外來之物,因而製作相應的抗體。477Please respect copyright.PENANAjQFPcjoCXh
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(圖3)因為康希諾疫苗所用的是人類常見的感冒病毒,約4-6成的人早已擁有對抗這感冒病毒的抗體,因此病毒還沒能進入細胞之前(圖2的步驟2),便早已被自身的抗體攔截。477Please respect copyright.PENANAU8sGMuw5ys
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而牛津所用的是黑猩猩所搵到的感冒病毒,原理上人體並沒有對應的抗體,因此亦相對上更易進入細胞。477Please respect copyright.PENANADtbc9oO2WX
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以這方面來看,牛津疫苗的設計比康希諾技勝一籌。477Please respect copyright.PENANA4HS4K7mn2m
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最近Bloomberg (Ref3)表示Cansino疫苗的保護效率達65.7%,而它跟Johnson&Johnson的疫苗一樣,均是一次性的方式注射。477Please respect copyright.PENANAsAXKi90oAk
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延伸閱讀:477Please respect copyright.PENANAS9X0KfFyRy
深入淺出–林鄭注射輝瑞/科興疫苗的最壞後果477Please respect copyright.PENANAxgm7DfiegE
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Ref1:https://science.sciencemag.org/content/370/6522/1263477Please respect copyright.PENANAZag0xV5xZt
Ref2:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067905/477Please respect copyright.PENANAo1plY1xyIN
Ref3:https://www.bloomberg.com/news/articles/2021-02-08/pakistan-says-cansino-s-covid-vaccine-shows-65-7-efficacy477Please respect copyright.PENANAc5NFXUbv7L