痴肥人士的患癌風險及死亡率均比健康人士為高。425Please respect copyright.PENANA3zKD1PZesv
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位於癌細胞在所位置附近的肥肪細胞,相信亦有份協助癌細胞助大的進程。425Please respect copyright.PENANAlzYBmFdu7J
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(圖2)從圖中的老鼠動物模型中可見,痴肥老鼠的腫瘤體積明顯比正常老鼠的為大。425Please respect copyright.PENANAXhx298IrvE
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痴肥老鼠的整體體重比正常老鼠的為重,雙方的肌肉重量並無太分別,唯痴肥老鼠的脂肪重量明顯比正常老鼠的為重。425Please respect copyright.PENANAuVV3L6BOtB
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(圖3)經過一系列的研究後,科學家發現脂肪細胞會供應Creatine給癌細胞,促進其生長。425Please respect copyright.PENANAJmSbPNiJX7
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如果剔除脂肪細胞其中一隻負責製造Creatine的蛋白酶、或者剔除癌細胞表面負責攝取Creatine的蛋白酶,雖並不會對老鼠整體重量有大影響,但可以清楚得到痴肥老鼠腫瘤的縮細;425Please respect copyright.PENANAG3zsmWKO37
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這效果只有在痴肥老鼠上才會出現,剔除相關的基因並沒有對健康老鼠的腫瘤體積有任何大影響。425Please respect copyright.PENANAYD4FuDIE5U
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重要的是,就算在老鼠餐單上加入大量Creatine,亦不會對腫瘤重量有影響,這亦表明了只有癌細胞旁脂肪細胞所供應的本土Creatine才會對腫瘤的發展有正面影響。425Please respect copyright.PENANAotRXQmAK24
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。425Please respect copyright.PENANAM52Pzv4MxV
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc425Please respect copyright.PENANAZ75g0vpOac
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。425Please respect copyright.PENANAxPBH9xkea7
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio425Please respect copyright.PENANAfvyU33W5II
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。425Please respect copyright.PENANAN6gfxzZ2jo
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Ref1:https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00056-5425Please respect copyright.PENANAwASiLLCBzc