癌細胞從原位轉移到另一器官,亦即是Metastasis,是癌病患者主要的死因。419Please respect copyright.PENANATnMtx9gM9Q419Please respect copyright.PENANAvXQwvetcDx
419Please respect copyright.PENANAtnb37GTJYR
「有趣的是」,癌細胞雖近乎不會轉移到肌肉位置裡頭,但卻能從遠處釋放物質,經由血管抵達肌肉位置,催使肌肉萎縮,亦即是癌症惡病質(cancer cachexia)。419Please respect copyright.PENANAfSO5wq98Xg
419Please respect copyright.PENANALtNyFOWzJg
(圖2)肌肉萎縮不但之令病人變得虛弱,難以接近正常劑量的化療,更為致命的是,當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候,病人便會因呼吸困難等問題而逝死。419Please respect copyright.PENANAkcHhg1iCJz419Please respect copyright.PENANACwFtNPvB5c
419Please respect copyright.PENANAfeW1AAF31A
早在1858年已有科學家指出cancer cachexia的存在,但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。419Please respect copyright.PENANAbOe0urShzu
419Please respect copyright.PENANAaYseNxfXrq
(圖3)現時有不少臨床研究希望可以制衡cancer cachexia,普遍均是從營養方面入手。419Please respect copyright.PENANA4Z6wguNBwj419Please respect copyright.PENANA5z9SzEF5MA
419Please respect copyright.PENANAHn0hkJkY0i
但結果大多數是只能夠增加病人的脂肪組織,而沒能夠填補已萎縮的肌肉。419Please respect copyright.PENANAeFvqMjEfnc
419Please respect copyright.PENANAb0xPHLMHLj
有一點值得注意的是,肌肉細胞並非是死去,純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快,因而形成萎縮。419Please respect copyright.PENANAklZxgY3LXc
419Please respect copyright.PENANAqtVbNi3HzK
419Please respect copyright.PENANAsbJnVkwmhR
(圖4)從研究Cancer cachexia的老鼠模型中可以看到,患癌的老鼠不但更為細小,其手腕的握力度亦有所下降。419Please respect copyright.PENANAz4APh6XMEh419Please respect copyright.PENANArPr5osoFV3
419Please respect copyright.PENANAy2RQ7WmheJ
觀察肌肉細胞橫切面的面積時,亦可以看到肌肉細胞的面積明顯有所縮細。419Please respect copyright.PENANAKmtKiiodZP
419Please respect copyright.PENANACm9RswCtjZ
419Please respect copyright.PENANA2RJYfCZ1Z5
419Please respect copyright.PENANAj1Ye7GCNOo
下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。419Please respect copyright.PENANAW5aBaIZ5ic
419Please respect copyright.PENANAhGBARDuCoB
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。419Please respect copyright.PENANABrpMHRtfqp
419Please respect copyright.PENANACstssY4Y7A
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc419Please respect copyright.PENANACtYvE4Bb3W
419Please respect copyright.PENANANScNo57ZHs
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。419Please respect copyright.PENANAKzdY1YgXsR
419Please respect copyright.PENANAD5LdCQTAxQ
Link:419Please respect copyright.PENANAiz8ZDNXkjw
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio419Please respect copyright.PENANAP40AfS1sYI
419Please respect copyright.PENANA50V4aRuI1v
419Please respect copyright.PENANAqtpPFM8toR
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。419Please respect copyright.PENANAcnScXwhlVW
419Please respect copyright.PENANA6UK0tcI41X
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/419Please respect copyright.PENANAayk6eh4HJO