從圖中可見,癌細胞所在的環境非常複雜。409Please respect copyright.PENANAjF0UEoGogj
癌細胞附近不只有著各種細胞,其就近的血管大多處於參差不齊的狀態,導致營養及氧氣難以順利到達癌細胞裡頭。409Please respect copyright.PENANAJKhRWE6Omk
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在這種「逆境」之中,癌細胞究竟有何手段求生呢?409Please respect copyright.PENANAbm1BOgc0Pq
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(圖2)在導管胰腺癌中,科學家發現癌細胞的所在位置含有大量名為CAM的細胞。409Please respect copyright.PENANAXw8jreBrvi
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經一系列的研究後,科學家發現這些細胞竟然是協助癌細胞長大的好幫手。409Please respect copyright.PENANAxEymYZUBy8
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(圖3)圖中為癌細胞如何利用周遭的CAM細胞供養自己的機制。409Please respect copyright.PENANAoNyJQrX7pv
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在營養短缺的環境下,癌細胞迫使周遭的細胞分解蛋白質供自己所用,從而渡過難關及繼續在逆境中成長。409Please respect copyright.PENANAUOVCba8LtH
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在老鼠的動物模型中,若然抑制CAM細胞進行自噬作用,癌細胞的體積的確是有所縮小,得以證實癌細胞會用盡身邊的一事一物從而壯大自己,在先天資源短缺的環境下亦能「自肥」。409Please respect copyright.PENANApyZGrjNKBZ
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Ref1:https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30102-2409Please respect copyright.PENANAcNIOE69hKb
Ref2:https://pubmed.ncbi.nlm.nih.gov/27509858/409Please respect copyright.PENANAfuXwtLiPyK