近日有急凍雞翼及其他產品被測量出擁有武肺存在,但武肺能否在雞翼或其他食物上大量繁殖呢?882Please respect copyright.PENANAMBMjrJ2Rbf
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答案是,不可以。882Please respect copyright.PENANAG0kaCgtfrv
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武肺進行大量繁殖的話,必需要借助活生生的細胞幫忙,而其中先決的一步就是要進入細胞體內。882Please respect copyright.PENANAZswvp7suqh
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武肺可否入侵細胞,基本上視乎可唔可以達成下列3個條件。882Please respect copyright.PENANAC44mfOAJl2
(圖1)882Please respect copyright.PENANASGEZCXKgTl882Please respect copyright.PENANASwVXmG13R8
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1. S protein與細胞表面的ACE2觸碰。882Please respect copyright.PENANAZ3JU5q5V3v
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2. 細胞表面ACE2與S protein的形狀吻合,亦即是「啱嘴形」。882Please respect copyright.PENANA2vmws7Ww5R
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3. 細胞表面擁有TMPRSS2蛋白質,能夠對S protein進行切割。882Please respect copyright.PENANACJ49HbctEA
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滿足3大條件後,病毒就有能力能夠入侵細胞。882Please respect copyright.PENANAKNHgEoZM3Z
當然,入侵細胞後還有很多因素決定武肺能否大量繁殖,但急凍雞翼連活生生的細胞也沒有,根本無可能可以大量繁殖。882Please respect copyright.PENANA4AvP7X0m0V
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何謂S protein和ACE2,可到我之前所寫的文章溫故知新。882Please respect copyright.PENANAdiVHE87ezD
https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/issue/9882Please respect copyright.PENANAvFcab7cZMC
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(圖2)882Please respect copyright.PENANA5TKgd6wRaC
第二點所謂的「啱嘴型」,所指的就是ACE2的形狀能否與武肺的S protein形狀吻合,就好像砌Puzzle一樣,兩者不吻合的話就無法連結一起,勉強亦無幸福。882Please respect copyright.PENANA6EiGUVzStI
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如圖中所見,正因為老鼠ACE2唔啱嘴型,所以武肺無法引致老鼠患上肺炎等病徵,袁教授等人因此亦改用啱嘴型的倉鼠作為武肺的動物實驗模型。882Please respect copyright.PENANAoWmU1kAyj6
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(Ref 1)有科學家嘗試將武肺打落豬、雞和鴨身上,最終無法在牠們的任何器官身上找到武肺,而且亦沒有出現任何病徵,因此斷定牠們並不會受到武肺感染。882Please respect copyright.PENANA0cschn6URf882Please respect copyright.PENANAlYEgAQwC72
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(圖3)882Please respect copyright.PENANAgzflyfI6OE
關於第三點,肺(Lung)及腎臟(Kidney)同樣擁有一定數量的ACE2及TMPRSS2(Ref2),因此將會成為武肺的主要針對對象。882Please respect copyright.PENANAuVNXEIKPYo
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而心臟(Heart) 同樣擁有一定數量的ACE2,某程度亦解釋了為何武肺患者康復後會被發現心臟出現異樣。882Please respect copyright.PENANAqPFqpQ1bpt
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而男性器官睪丸(Testis),亦是ACE2數量較多的器官(圖中沒有列出),所以,嗯......882Please respect copyright.PENANAI7qzIJVDr2
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio882Please respect copyright.PENANA1M5OYl4GxQ
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Ref1:https://science.sciencemag.org/content/368/6494/1016882Please respect copyright.PENANABikfurkpje
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Ref2:https://www.sciencedirect.com/science/article/pii/S221323172030820X#fig1882Please respect copyright.PENANAJn7xF4p0dv