癌細胞經常被描繪為極度嗜糖。的而且確,大部份的癌細胞對比同等類型的正常細胞均會攝取更多的糖份。469Please respect copyright.PENANA9BNjM4rttA
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箇中的原因至少有三:469Please respect copyright.PENANA1mTGDoZLdQ
1.致癌基因的表達率增加469Please respect copyright.PENANAeSrBNEDkEJ
2.新陳代謝酶素變異469Please respect copyright.PENANAj24l8MQeN6
3.周遭環境缺乏氧氣469Please respect copyright.PENANATVQPku5bI7
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(圖2)沒有氧氣的話,脂肪及氨基酸並不能轉化成為可供細胞所用的能源。469Please respect copyright.PENANAFtvmE3i10M
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然而,糖份在擁有氧氣或缺乏氧氣的情況下,均可轉化成為能源。469Please respect copyright.PENANAPnThRP3mUg
因此,當癌細胞處於缺氧狀態的時候,便會增加對糖份的依賴。469Please respect copyright.PENANA8bfh7WfKTD
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(圖3)正常的細胞有著一套完善的機制控制著其生長速度,而這些機制大多數時候均會在癌細胞發發生的基因變異影響下作廢,促使癌細胞能夠無止境地生長及繁殖。469Please respect copyright.PENANAooswdadBwz
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當一個細胞需要繁殖的時候,細胞膜以及DNA是不可或缺的元件。469Please respect copyright.PENANAlWbqaRftzi
而在糖份分解的過程中,所涉及的代謝物均能參與細胞膜和DNA的製作。469Please respect copyright.PENANAKFaeIUUgdj
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亦即是說,癌細胞不斷無止境地生長,導致內部位置沒有足夠氧氣,正好更能觸發更多糖份的攝取,繼續製作繁殖所需的細胞組件。469Please respect copyright.PENANALrIfiS30yl
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但是,若氧氣沒能抵達癌細胞的話,那又如何能夠獲取營養呢?469Please respect copyright.PENANAxC2UFMDfOJ
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其中的一種渠道,就是從鄰近死去的細胞獲取。469Please respect copyright.PENANAa9LD6JiI5N
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詳見可閱:469Please respect copyright.PENANABlYa3BIwe7
三十秒科學–化療效果參差的其中一道原因469Please respect copyright.PENANAzbHVyTSFS9
- 分享自 LIHKG 討論區469Please respect copyright.PENANAn5AwK2AtVW
https://lih.kg/2378848469Please respect copyright.PENANAV6eviGspVf
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正因如此,腫瘤的核心大多是已死去的細胞,而其外部則是不斷繁殖的細胞。469Please respect copyright.PENANAuVjlfTg8kM
而經過一段時間的繁殖後,早前的「外部」細胞便成為「核心」,成為鄰近細胞的糧食。469Please respect copyright.PENANA14EChWM0wX
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日復如此,腫瘤亦得以無止境助大。469Please respect copyright.PENANA4FF7BSSjkh
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