肌肉大概佔據身體重量的40%。407Please respect copyright.PENANAoEhGiUr0Gj407Please respect copyright.PENANApFbmHFD6lt
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。407Please respect copyright.PENANALqzSCdCUNV
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。407Please respect copyright.PENANAGeMhUb1aZs407Please respect copyright.PENANA23SX1Utt9v
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。407Please respect copyright.PENANAc4rJuvTxgF
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。407Please respect copyright.PENANAdVrxHSaD7p
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。407Please respect copyright.PENANAJUXX7YEipk407Please respect copyright.PENANAEvQl5chZTh
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。407Please respect copyright.PENANAbLl3nSk2sI
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。407Please respect copyright.PENANAhgWL6nh3Xv
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。407Please respect copyright.PENANAuE6KtearPs
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。407Please respect copyright.PENANAEeruVR0cZi
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。407Please respect copyright.PENANAIQnpe7ON5U
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。407Please respect copyright.PENANAr3Y2Gzmaom
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Link:407Please respect copyright.PENANARFYjeCcgKv
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio407Please respect copyright.PENANAeawiMsmNG5
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。407Please respect copyright.PENANAOggGDKY5NL
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059407Please respect copyright.PENANAa4t9ghNoui