肌肉大概佔據身體重量的40%。406Please respect copyright.PENANADvcNuLgr8M406Please respect copyright.PENANAhbkdZvy3Ww
406Please respect copyright.PENANAEZBPEbLVvV
踏入50歲後,平均每10年就會有15-30%的肌肉流失。406Please respect copyright.PENANAqgpk2GmNtW
406Please respect copyright.PENANAR1shjYi4RD
(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。406Please respect copyright.PENANA8vAV5fhj9A406Please respect copyright.PENANAv44afw1fjj
406Please respect copyright.PENANAs0UR91eTsE
而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。406Please respect copyright.PENANAgaKOdKHTMY
406Please respect copyright.PENANA9x1YJuLvGy
(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。406Please respect copyright.PENANAoUMzHgLPTX
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。406Please respect copyright.PENANATkDKg6Nmm4406Please respect copyright.PENANAh9ZXNRXGv7
406Please respect copyright.PENANAS6EkiMekKE
當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。406Please respect copyright.PENANAT3E8AiiB2W
406Please respect copyright.PENANACiu1wVz4PB
相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。406Please respect copyright.PENANAPSjnjD2W1O
406Please respect copyright.PENANAO7mQzH6ZwO
這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。406Please respect copyright.PENANAUc4hSOcExy
406Please respect copyright.PENANAYqC6hPS5x4
現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。406Please respect copyright.PENANATownj7wjEL
406Please respect copyright.PENANAHVZZFBUxfe
只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。406Please respect copyright.PENANAt0Yfz8QqTr
406Please respect copyright.PENANAPO5qmUu0LW
406Please respect copyright.PENANAyBW8cpdXvF
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。406Please respect copyright.PENANAk8tpAJhx36
406Please respect copyright.PENANAqiqiY3CQwQ
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc406Please respect copyright.PENANAYPMQonOVz4
406Please respect copyright.PENANAHDLyIVqBKe
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。406Please respect copyright.PENANAYdifBtvToI
406Please respect copyright.PENANAkHMWaT7Wrt
Link:406Please respect copyright.PENANAnQhvkeENQI
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio406Please respect copyright.PENANA98oidr18uX
406Please respect copyright.PENANAfH9VSpgTMI
406Please respect copyright.PENANA0EJfT0CXPC
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。406Please respect copyright.PENANAIqPKjKJRy4
406Please respect copyright.PENANARgDDsh7igF
Ref1:https://science.sciencemag.org/content/371/6528/eabc8059406Please respect copyright.PENANAwIhJgkwOcH