黃金葡萄球菌這字眼,周不時亦會在新聞媒體聽得到。644Please respect copyright.PENANAD5Ku4uAZPS
644Please respect copyright.PENANAcYfMzdnYHu
644Please respect copyright.PENANA7FLdkCppsi
它之所以被冠以黃金這稱號,是因為它能夠製造大量金黃色的葡萄球菌黃素 (Staphyloxanthin),以及微量黃色化合物4,4‘-Diaponeurosporene。644Please respect copyright.PENANATtVEnDPrdo
644Please respect copyright.PENANAqmqz85nISM
(圖2)當細菌入侵腸道的時候,我們的腸道內壁細胞及前來救駕的免疫細胞會釋出微量雙氧水等的游離基(Reactive oxygen species),對細菌進行攻擊。644Please respect copyright.PENANAdcwMDCuQPB
644Please respect copyright.PENANAwnZFqZKlrV
644Please respect copyright.PENANAzFsdWkMTxC
但黃金葡萄球菌的金黃色葡萄球菌黃素及另外那種黃色化學物正是能夠中和游離基攻擊的色素,因此免疫系統所產生的游離基攻擊對它傷害不大。644Please respect copyright.PENANAjHrwGoaxlF
644Please respect copyright.PENANA7QMTwUl7lt
然而,如果刪去製作色素的蛋白酶,「黃金」葡萄球菌失去抵擋游離基的手段,對宿主的感染力亦因而大大減低。644Please respect copyright.PENANAVNJYRPUQgP
644Please respect copyright.PENANAh5hraA5Myl
(圖3)同時間,若將負責製造黃色色素的蛋白酶從黃金葡萄球菌轉移到另一款葡萄球菌,獲得了色素製作能力的它在老鼠身上所造成的感染傷害亦更之為強,引證色素對於細菌感染力的重要性。644Please respect copyright.PENANAss1GZeu3es
644Please respect copyright.PENANAzPA3LOyGhj
644Please respect copyright.PENANAroH4XkDT5A
(圖4)再舉另外一道例子,Cryptococcus neoformans是一種真菌(fungus),644Please respect copyright.PENANAr5WJlC8myd
它能夠製作黑色素(Melanin),亦即是上集所談及決定髮膚眼色的色素。644Please respect copyright.PENANASYP50fxMZT
644Please respect copyright.PENANAkomBkhve6u
644Please respect copyright.PENANA3tfqkPZNha
黑色素除了跟金黃色葡萄球菌黃素一樣能夠抵擋游離基的攻擊外,其本身帶有負極的性質更能與兩隻帶有正極的常用抗真菌素(amphotericin B 及 caspofungin)結合,大大削弱藥物傷害真菌的能力。644Please respect copyright.PENANA75F4V1zVO9
644Please respect copyright.PENANAMnvD0YTHRQ
644Please respect copyright.PENANA7LkqPCMs7V
延伸閱讀:644Please respect copyright.PENANAXhTvgA7USA
深入淺出–從深海生物中發掘出抗真菌藥物644Please respect copyright.PENANA9tl0ICthsx
- 分享自 LIHKG 討論區644Please respect copyright.PENANAa62cQJlFMu
https://lih.kg/2296185644Please respect copyright.PENANAH7J4npRU9E
644Please respect copyright.PENANAnbzmBwyVde
644Please respect copyright.PENANASwK9Ad3OUw
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。644Please respect copyright.PENANAf5VnThqHS5
644Please respect copyright.PENANAn1qODIyLMi
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc644Please respect copyright.PENANAaA7SXfliOY
644Please respect copyright.PENANAvHKK9ZYGvG
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。644Please respect copyright.PENANAl5P9YUOk5t
644Please respect copyright.PENANAkultKda7d2
Link:644Please respect copyright.PENANAiu6aSJu1gs
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio644Please respect copyright.PENANAbEjG3c00vf
644Please respect copyright.PENANA9ITRTq77HM
644Please respect copyright.PENANABDjc6I4wic
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。644Please respect copyright.PENANAkiP2IqVn2p
644Please respect copyright.PENANAHCf9Gy4zl9
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743764/644Please respect copyright.PENANAzDPiur0T6F