癌細胞的新陳代謝與普通細胞有著顯著的分別,原因是癌細胞需要截然不同的新陳代謝來滿足生長的需要。701Please respect copyright.PENANAaHfzMiQYc1
701Please respect copyright.PENANAVHjxK8IMRF
但是,當癌細胞從原有位置轉移到另一位置後,其新陳代謝有會否有所轉變呢?701Please respect copyright.PENANAoPUSdyfEgV
701Please respect copyright.PENANAtPmd684Glm
701Please respect copyright.PENANAd0IxHSTw87
(圖2)mTORC1是其中一隻掌管細胞生長的蛋白質,而有研究(Ref1)指出,從乳癌轉移到肺部的癌細胞,其mTORC1所帶來的效果更為強大,能令癌細胞生長得更快。701Please respect copyright.PENANAPIhrf49sko
701Please respect copyright.PENANA1HhmsrcQ7i
701Please respect copyright.PENANAbO7fnkfq0q
(圖3)科學家發現,肺部含有充足的Pyruvate代謝物,而利用藥物阻擋「乳癌轉移過來的肺癌」吸收Pyruvate的話,便能減低mTORC1的功效。701Please respect copyright.PENANAQ5HP2a7p9s
701Please respect copyright.PENANAbjGlJvQUSZ
701Please respect copyright.PENANAyaPiSENtOr
但奇怪的是,用藥物阻擋原發腫瘤乳癌吸收Pyruvate的話,mTORC1的功效並不會有所減低,腫瘤生長的速度並無任何特別變化。701Please respect copyright.PENANAuHafxPO92x
701Please respect copyright.PENANAeftmDRK1Fn
這顯示出,癌細胞從原有地方轉移到另一位置後,其新陳代謝亦有著顯著的變化。701Please respect copyright.PENANAzh11tUIr7q
這有可能是因為第二處位置的生長環境有所不同,故此癌細胞需要調節其新陳代謝來適應新環境。701Please respect copyright.PENANAcCd7jbp2Oc
701Please respect copyright.PENANAhyOxydZwKU
在乳癌轉移到肺部的癌細胞,我們可透過針對Pyruvate的吸收來減慢他們的生長,但這是否只適用於從其他位置轉移到肺部的癌細胞,以及乳癌轉移到其他位置的癌細胞,那還需要進一步的研究確實。701Please respect copyright.PENANAAI0WusKNDE
701Please respect copyright.PENANA1lXGtV2ORv
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。701Please respect copyright.PENANA7JgRnAW9rC
701Please respect copyright.PENANA6jvO48Smgy
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc701Please respect copyright.PENANAitVYYgWAo7
701Please respect copyright.PENANAu5mt0Dr53Y
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。701Please respect copyright.PENANATEzFQzkUxo
701Please respect copyright.PENANA7dWhHNiRL0
Link:701Please respect copyright.PENANAB5bnixqk6i
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio701Please respect copyright.PENANAJ63MIeadWy
701Please respect copyright.PENANAokDDpnjY8Q
701Please respect copyright.PENANANIKgiundHr
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。701Please respect copyright.PENANAfGcEXuAhDV
701Please respect copyright.PENANAUaYPcvm8Sc
Ref1:https://www.sciencedirect.com/science/article/pii/S1097276520308273701Please respect copyright.PENANAhTZn0diV1j