骨髓(Bone Marrow)是不少幹細胞的聚居地,而紅血球、白血球、血小板等都是從骨髓裡頭的幹細胞而來。1046Please respect copyright.PENANAvemSzVH4Zn
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(圖2)老鼠在跑動滾輪運動四星期後,其頭腦骨髓裡專門負責製造免疫細胞的幹細胞數量並沒有明顯改變。1046Please respect copyright.PENANAuQIBagCs3i
而在運動時候所用到的腳骨內,專門負責製造免疫細胞的幹細胞數量則有所增加。1046Please respect copyright.PENANA8zvQyUylcW
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(圖3)研究發現(Ref1),骨髓裡某類型的幹細胞表面有著名為Pizeo1的蛋白質。1046Please respect copyright.PENANAiYSXOkYDQU
當它受到運動等的物理刺激後,便會催動自身幹細胞演變成為骨細胞,同時亦會釋放物質,誘導其他幹細胞演變成為與免疫系統有關的細胞。1046Please respect copyright.PENANADiPQwkte9S
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缺乏Pizeo1蛋白質的老鼠當受到細菌感染的時候,所產生的免疫系統細胞數量亦明顯比擁有Pizeo1蛋白質的老鼠為少。1046Please respect copyright.PENANAdBFjAbm0xJ
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而除運動外,歲數亦會影響與免疫系統有關的幹細胞數量,18個月大的老鼠其數量明顯少於2個月大的老鼠。1046Please respect copyright.PENANAcSL50h54LB
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若人類亦是採用相同機制的話,這或許是其中一道解釋運動能提升身體免疫力的理據。1046Please respect copyright.PENANAXpIsoHbVSA
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Ref1:https://www.nature.com/articles/s41586-021-03298-51046Please respect copyright.PENANAHi9mgwJtQ2