最為理想的檢測武漢肺炎方法,當然是要準確同快速兩者兼備,不需任何儀器家用便能做到為之更佳。516Please respect copyright.PENANAVmW1Bkha8r516Please respect copyright.PENANAvwA0nGEy9Z
516Please respect copyright.PENANAkMwINkxMjt
現今最為標準的檢測方法RT-QPCR,但整個過程接近耗時2小時,而且亦需要實驗室PCR儀器及專業人士確認結果的可信性。516Please respect copyright.PENANAO5JeRUMpNU
516Please respect copyright.PENANAXuQw7ONTre
較為快捷但並未全面通行的方法為RT-LAMP,整個過程約耗時30-50分鐘,可套用不同方法展示結果,最高靈敏度比RT-QPCR約低10倍。516Please respect copyright.PENANASXEsgDSaQO
516Please respect copyright.PENANAD12N9hWaP9
整個過程受著需要在攝氏65度運行的限制,距離家用化仍擁有著些許的不便。516Please respect copyright.PENANA8w4A91PG59
516Please respect copyright.PENANAmYsgjtpw8W
516Please respect copyright.PENANAkK5DvyS0PX
(圖2)最近有科學家研發一套名為SENSR的檢測方法(Ref1),耗時約30-50分鐘,但全程只需在攝氏37度運行!516Please respect copyright.PENANAoV0ihAxXrc516Please respect copyright.PENANA4M5jic6QxZ
516Please respect copyright.PENANAC1Udl0jb9D
他們嘗試利用最為準確的RT-QPCR方法作出對比,40個樣本之中,有39個達一致結果。516Please respect copyright.PENANAaNo0mJwlO3
整個檢測方法主要包含四大組件,如圖中所示。516Please respect copyright.PENANAFD5gf9yOAY
516Please respect copyright.PENANAhq6UuKDf5N
516Please respect copyright.PENANAI2HyYdC63A
(圖3)經過精心的設計,兩隻Probes會辨認武肺病毒RNA前後二段位置。516Please respect copyright.PENANAm8xDhO3fGZ
兩隻Probes同時辨認成功後,名為SplintR ligase的蛋白質便會將兩隻Probes連成一起。516Please respect copyright.PENANAFsOsYQqfaM516Please respect copyright.PENANA8Tbr6XGIkt
516Please respect copyright.PENANAayR4JCflFz
516Please respect copyright.PENANAzO4YwPhLSs
(圖4)連成一起的Probe將會被T7 RNA polymerase 利用,生產出特殊結構的物質。516Please respect copyright.PENANAvFIgOFU91o516Please respect copyright.PENANADYQLKSaBdP
516Please respect copyright.PENANAXrfx3OkHxq
這些特殊結構物質會Fluroescence Dye結合,發出螢光,而沒有與特殊結構物質結合的Fluroescence Dye則不會發出螢光。516Please respect copyright.PENANAS85G5d2P4K
516Please respect copyright.PENANAZSGeJOV2Te
516Please respect copyright.PENANAjlCQODYfmT
(圖5)只要將病人口水及能夠打破病毒外層的化學物與檢測方法組件放在一起,在攝氏37度的環境下,半小時後便能憑著螢光強度獲取結果。516Please respect copyright.PENANAhOA8PyMKvz516Please respect copyright.PENANA5MzeO429NC
516Please respect copyright.PENANAuTITDQIdvg
沒有螢光,意指沒有武肺病毒的存在。516Please respect copyright.PENANAxEoabXUR9p
而螢光越強,則代表武肺病毒數量就越多。516Please respect copyright.PENANAd4CzxQfHvY
516Please respect copyright.PENANAJiMYjKQINi
若然整套檢測方法能長久地與RT-QPCR的結果吻合的話,甚至能改良至更短時間完成的話,那些健康碼或健康護照的系統便完全成為被科技淘汰、多餘無用的產物。516Please respect copyright.PENANAhj2xjspZWI
516Please respect copyright.PENANAhWBsPWi74C
516Please respect copyright.PENANA9IyQwevl2W
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。516Please respect copyright.PENANAjVYuvlJWck
516Please respect copyright.PENANA8L6SDSE6vo
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc516Please respect copyright.PENANApYJSFuNYJW
516Please respect copyright.PENANAPpz4HmfHmd
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。516Please respect copyright.PENANAzDN2TFekd2
516Please respect copyright.PENANABCpOiQUh5y
Link:516Please respect copyright.PENANA5oZ3GxxdhD
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio516Please respect copyright.PENANAqDQZmna7vl
516Please respect copyright.PENANAsZA6TuUdIP
516Please respect copyright.PENANADeOvN9jbVi
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。516Please respect copyright.PENANAOHv2Q1Fjc1
516Please respect copyright.PENANAi0uDuyXBSP
516Please respect copyright.PENANAphvlwA2eA9
Ref1:https://www.nature.com/articles/s41551-020-00617-5.epdf?sharing_token=jyB1FrYxTMs2zz7531NEC9RgN0jAjWel9jnR3ZoTv0Oek8rnwPluVmxh8oas6RXA_yYuSqspJD8rPlYkIjcQAnYsXIpSHTS1rRw2pBOABq2RcPNywJhYXk5RtoOUasrjInaGxrHnZw-U2KJCVSypN2TLCfr8XdJlRq3q0or2Vs8%3D