癌細胞轉移,即是從原來的位置轉移到另一地方。370Please respect copyright.PENANAr3wEMbsy0q
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利用老鼠作為癌細胞轉移研究的話,科學家又是如何得知癌細胞是否有出現轉移的過程,以及所轉移的地方呢?370Please respect copyright.PENANAgq0EyXuJrL
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(圖2)探知癌細胞轉移而又不需殺害老鼠的其中一道手段,就是藉助螢火蟲的螢光素酶幫助。370Please respect copyright.PENANAEV46an5apH
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螢光素酶(Luciferase)能夠將螢光素(Luciferin)轉化成為另一物質,同時亦會發出螢光。370Please respect copyright.PENANAPpwRQDNUkT
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換句話說,利用分子生物學技術強迫癌細胞表達螢光素酶的話,當他們遇上螢光素的時候,便會在其所在的位置發出螢光。370Please respect copyright.PENANAAkb23obwnl
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(圖3)往老鼠移植含螢光素酶的癌細胞,到達需要進行研究時間的時候便為牠們注射Luciferin,Luciferin會經由血液循環系統走遍全身,過一段時間後再對牠們進行麻醉,並用儀器探測螢光,便可以得知癌細胞的大小及所在位置。370Please respect copyright.PENANAt3ubT68spU
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將右圖對比左圖,便可清晰得知右圖的癌細胞出現了轉移。將此螢光方法配合藥物或基因改造手段,便可得知所對應的醫學方法能否修成正果。370Please respect copyright.PENANA50T4xmhqFW
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。370Please respect copyright.PENANASQKmKet5ji
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc370Please respect copyright.PENANA1h5nYnhg2c
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。370Please respect copyright.PENANAgobPwe3HwA
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Link:370Please respect copyright.PENANAY7TXMt5u4s
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio370Please respect copyright.PENANAihQNSwwh30
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。370Please respect copyright.PENANA9wVxRg7saD
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Ref1:https://pubmed.ncbi.nlm.nih.gov/27974793/370Please respect copyright.PENANAVE4OVa5KQJ