癌細胞轉移,即是從原來的位置轉移到另一地方。343Please respect copyright.PENANABjYjMK8Ja0
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利用老鼠作為癌細胞轉移研究的話,科學家又是如何得知癌細胞是否有出現轉移的過程,以及所轉移的地方呢?343Please respect copyright.PENANABFbTMoFlyB
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(圖2)探知癌細胞轉移而又不需殺害老鼠的其中一道手段,就是藉助螢火蟲的螢光素酶幫助。343Please respect copyright.PENANAue61qFuGw0
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螢光素酶(Luciferase)能夠將螢光素(Luciferin)轉化成為另一物質,同時亦會發出螢光。343Please respect copyright.PENANAyc6lU7AQEA
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換句話說,利用分子生物學技術強迫癌細胞表達螢光素酶的話,當他們遇上螢光素的時候,便會在其所在的位置發出螢光。343Please respect copyright.PENANAxMWdCzd1xH
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(圖3)往老鼠移植含螢光素酶的癌細胞,到達需要進行研究時間的時候便為牠們注射Luciferin,Luciferin會經由血液循環系統走遍全身,過一段時間後再對牠們進行麻醉,並用儀器探測螢光,便可以得知癌細胞的大小及所在位置。343Please respect copyright.PENANAIJd6xHoJT2
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將右圖對比左圖,便可清晰得知右圖的癌細胞出現了轉移。將此螢光方法配合藥物或基因改造手段,便可得知所對應的醫學方法能否修成正果。343Please respect copyright.PENANA4bQpglvz1q
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio343Please respect copyright.PENANAGInk6FHDlo
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Ref1:https://pubmed.ncbi.nlm.nih.gov/27974793/343Please respect copyright.PENANAVcjDUOLS7D