隨著針對癌細胞新陳代謝的研究逐漸倍增,配合飲食來醫治癌症這方面亦開始得到關注。419Please respect copyright.PENANANTnfMZvAzw
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現今有不少利用實驗室細胞及動物的研究指出,低卡路里餐單能加強化療藥物醫治癌症的效果。科學家們對此曾提出不少理論試圖解釋這現象,但現今並沒有一道能獲取大部份人共識的理論。419Please respect copyright.PENANAWeVarZuPjE
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(圖2)有一項人體臨床研究找來129名乳癌病人(Ref1),65人在療程中進食低卡路里餐單,而另外64人則沿用正常餐單。419Please respect copyright.PENANAQXBqx66ieA
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奈何因為味道及食慾等問題,最終只有22人能夠忍耐低卡路里餐單4星期,13人能夠忍耐8星期整個研究進程。419Please respect copyright.PENANANueoZOYRdk
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正常餐單那方,亦有5名病人想在療程中途嘗試一下低卡路里餐單。419Please respect copyright.PENANAbVLOkExYkh
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(圖3)圖中為低卡路里餐單的時間表。第一日攝取的總卡路里為1200,而之後的三日則為200卡路里,以碳水化合物為主。419Please respect copyright.PENANAG9ZcYLTS4Q
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第四日將會進行化療,而整個週期將重覆8次。419Please respect copyright.PENANAcfQl0flsMp
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(圖4)文中並沒有列出正常餐單的成份,但從文中結果的血液各指標中可以看得到,低卡路里餐單的病人,血液酮體含量比正常餐單的病人為高,而胰島素含量則為低。419Please respect copyright.PENANA78HSdVXdJL
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這至少證明了低卡路里餐單的病人是一直處於「飢餓」的狀態。419Please respect copyright.PENANAnv1Ms6OBWu
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(圖5)遵從低卡路里餐單的病人,化療3小時之後,某一組別的免疫細胞所受到的DNA傷害比正常餐單的人為低,為正面的良好效果。419Please respect copyright.PENANAV8xqXA1Jfv
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但低卡路里餐單能否使化療效果事半功倍,還需要更多的病人數量才能得出結論。419Please respect copyright.PENANApJTrmpMrf0
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另一方面,開發出能夠讓病人廣泛接受的低卡路里餐單,亦是一道需要關注的問題。419Please respect copyright.PENANAe2nxT8iqlp
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。419Please respect copyright.PENANAxZiZF2L8p8
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Ref1:https://www.nature.com/articles/s41467-020-16138-3#Sec20419Please respect copyright.PENANAu0Hg7mSxWN