注射武肺疫苗的主要目的,就是誘導身體產生對抗武肺病毒的抗體。435Please respect copyright.PENANAk1Emgxim9h
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但身體製造抗體需時,而且免疫系統薄弱的人士亦有可能沒法製造足夠數量的抗體。在這層面上,直接注射人造抗體的話,便能免去這兩道隱憂。435Please respect copyright.PENANA2Tvs6mAUTS
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(圖2)從圖中所見,檢測者身體含有武肺抗體的話,身體的病毒數量相對上亦會較少,反之亦然。435Please respect copyright.PENANAaKfVFsaZFr
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可見病毒數量與體內抗體含量有著反比的關係。435Please respect copyright.PENANAzkyb2d24ei
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(圖3)現今有一推斷,體內武肺病毒數量越多的話,出現重症的機會亦會相繼增加。435Please respect copyright.PENANAFcZRU2sDKo
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針對這一點,REGN公司進行臨床測試,為武肺患者注射兩款武肺人造抗體435Please respect copyright.PENANA05tY3TDW3J
casirivimab (REGN10933) 和imdevimab (REGN10987),435Please respect copyright.PENANAfmbqpS8Tsq
觀察能否透過注射人造抗體來減低體內病毒的數量(Ref1)。435Please respect copyright.PENANAAYhbmWkNzb
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(圖4)分別往測試者注射安慰劑(灰線)、2g人造抗體(藍線)和8g人造抗體(綠線)後,可以見得到接受人造抗體注射的人士,其病毒在體內的下降速度比注射安慰劑的來得更快。435Please respect copyright.PENANAYX1VoSIK54
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(圖5)但若然在注射前已被驗出擁有武肺抗體的話,額外的人造抗體注射並不會導致病毒有顯著的加快下跌(右圖);這有可能是體內的抗體本身已足夠應付現況。435Please respect copyright.PENANAplF7ff4cCM
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(圖6)值得留意的是,本身病毒數量越多的話,人造抗體所促使的病毒量下跌效果便會越見明顯。435Please respect copyright.PENANA8s1Ex0KUtU
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亦即是代表當體外病毒數量超過某一定數量的時候,體內自身的抗體便會未能足以應付現況,而此時候所注射的人造抗體便會派上用場。435Please respect copyright.PENANAl2pIUnGyYp
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(圖7)人造抗體注射後的第28日,其濃度亦相對非常穩定,能給予注射人士一道保護時間。435Please respect copyright.PENANA4HFjjYQtPn
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人造抗體雖能加快病毒下降的速度,但能否預防重症這一方面並未有充份證據支持。435Please respect copyright.PENANAr295dfNAq9
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而當患者已出現嚴重症狀後,注射人造抗體能否緩和或解決症狀亦是相當成疑。435Please respect copyright.PENANAZmrRIK7Hy3
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但無論如何,若然想達到在短時間內減低體內病毒的數量,人造抗體相信是其中一道的選擇。435Please respect copyright.PENANA9hL8IPRcR0
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMoa2035002435Please respect copyright.PENANAT2UavSP9BB