痴肥一直被譽為會增加患上糖尿病的機會。而箇中的理論,現今仍有著爭議的空間。427Please respect copyright.PENANAvPaQhpwFXl
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本集將會討論眾多理論之中的其中一種,adipose tissue expandability hypothesis。427Please respect copyright.PENANA8NgYhfyegg
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(圖2)Adipose tissue expandability hypothesis的理論就是,身體專責儲存脂肪的脂肪細胞不勝負荷,無法再繼續膨脹增大儲存脂肪。427Please respect copyright.PENANAK1bGJmlS1F
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正因如此,身體其他的細胞例如心臟細胞、肌肉細胞、胰臟細胞等亦唯有幫忙儲存脂肪。427Please respect copyright.PENANAX4NSPgkAvo
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而這樣做的後果不但會損毀各種細胞的運作及功能,亦大大減低它們對胰島素的反應,導致血糖長期高企(糖尿病)。427Please respect copyright.PENANABH5sPW6pat
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(圖3)同時間,歲數增長亦是增加患上糖尿病的風險。427Please respect copyright.PENANA1QfjjyH1pg
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無獨有偶,處於45-65歲的癡肥患者,其真正專責儲存脂肪的脂肪細胞存量是比同齡健康人士少25%左右。427Please respect copyright.PENANAItjnNdGoRy
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而天生因基因變異(PPARy, Sepin/ BCSL2, Lamin A和AKT2)而患上全身脂肪失養症的患者,脂肪細胞比例比正常人為少,其身體細胞出奇的更容易對胰島素不產生反應,導致更容易患上糖尿病。427Please respect copyright.PENANAP6bLVqYgCf
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這兩點亦是Adipose tissue expandability hypothesis的重要支持理據。427Please respect copyright.PENANAWUG35LaoMP
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Ref1:https://www.sciencedirect.com/science/article/pii/S0308814620325899?via%3Dihub#t0010427Please respect copyright.PENANAJYPmS2x4cH