藥物的效用有時候因人而異,其中一道原因,可以歸究於每個人體內的腸道細菌品種有所不同所致。377Please respect copyright.PENANAHOkEZc296X
377Please respect copyright.PENANALx0diyAbz9
377Please respect copyright.PENANA1ZS3sXGGm5
(圖2)口服藥物要抵達血管循環系統的話,無可避免將會途經我們的腸道。377Please respect copyright.PENANAiosyq2yFqL
而我們腸道的細菌有能力改造或代謝藥物,因而改變藥物結構及其效用。377Please respect copyright.PENANA9A789Sc2ku
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(圖3)有科學家找來人體最為常見的76種腸道細菌品種,與271款不同界別常用的藥物共同放在一起12小時。377Please respect copyright.PENANA6RCohqOlNk
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最終發現,271款藥物中,有多達176款藥物的濃度在被至少一種腸道細菌影響下,濃度減少了20%;377Please respect copyright.PENANAdjoXPvIZ4O
而這些腸道細菌品種每款可以代謝11-95款藥物不等。377Please respect copyright.PENANA3h6vq4Kjy6
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用上老鼠作動物模型,科學家更能找出所屬細菌哪一條基因負責消化/代謝藥物,引證腸道細菌影響藥物吸收的理念。377Please respect copyright.PENANAXF2P70klFN
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倘若你腸道恰巧住有細菌A,而細菌A又有能力吸收你所口服的藥物,那麼藥效便有可能會大大減低。377Please respect copyright.PENANAIQhd76PMt9
377Please respect copyright.PENANAWHWSpWNjIY
血液注射而非口服的藥物將有機會不受此限,因為藥物並不需一定要經過腸道裡頭。377Please respect copyright.PENANA1EcapZS6GR
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。377Please respect copyright.PENANAlxdU6OYdVP
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc377Please respect copyright.PENANA8L8sLRjY8J
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。377Please respect copyright.PENANAThZM8QZgsE
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Link:377Please respect copyright.PENANAeXNN0koEDe
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio377Please respect copyright.PENANA2aoYvFyw74
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。377Please respect copyright.PENANABEeD2iQAK2
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Ref1:https://www.nature.com/articles/s41586-019-1291-3377Please respect copyright.PENANAe9UdcFz7UW