從圖中可見,癌細胞所在的環境非常複雜。377Please respect copyright.PENANAqQkd9GtGf5
癌細胞附近不只有著各種細胞,其就近的血管大多處於參差不齊的狀態,導致營養及氧氣難以順利到達癌細胞裡頭。377Please respect copyright.PENANA08vwQixN7f
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在這種「逆境」之中,癌細胞究竟有何手段求生呢?377Please respect copyright.PENANA9fte5hhBsL
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(圖2)在導管胰腺癌中,科學家發現癌細胞的所在位置含有大量名為CAM的細胞。377Please respect copyright.PENANAywBF5KWSMn
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經一系列的研究後,科學家發現這些細胞竟然是協助癌細胞長大的好幫手。377Please respect copyright.PENANAot0747Bxlp
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(圖3)圖中為癌細胞如何利用周遭的CAM細胞供養自己的機制。377Please respect copyright.PENANAtZ5KbqUfRV
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在營養短缺的環境下,癌細胞迫使周遭的細胞分解蛋白質供自己所用,從而渡過難關及繼續在逆境中成長。377Please respect copyright.PENANAQStkWXTgMC
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在老鼠的動物模型中,若然抑制CAM細胞進行自噬作用,癌細胞的體積的確是有所縮小,得以證實癌細胞會用盡身邊的一事一物從而壯大自己,在先天資源短缺的環境下亦能「自肥」。377Please respect copyright.PENANAvqS6vXasqp
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Ref1:https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30102-2377Please respect copyright.PENANA9oHh7n082O
Ref2:https://pubmed.ncbi.nlm.nih.gov/27509858/377Please respect copyright.PENANAo7f3JUtUpC