當細胞裡頭出現多餘或者已受損毀的物質，又或者是細胞面臨營養不足的情況，細胞便會啟動名為自噬(Autophagy)的機制，依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪，供自己能量或物質所需。448Please respect copyright.ＰＥＮＡＮＡSOq0QkGPt6
448Please respect copyright.ＰＥＮＡＮＡxYa7bnezse
448Please respect copyright.ＰＥＮＡＮＡIqdKcSW8hY
早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。448Please respect copyright.ＰＥＮＡＮＡJvEkcQyxlr
三十秒科學–癌細胞也會自肥？448Please respect copyright.ＰＥＮＡＮＡ5LsnC0T3HD
- 分享自 LIHKG 討論區448Please respect copyright.ＰＥＮＡＮＡVigwnFuoMI
https://lih.kg/hgfcNS448Please respect copyright.ＰＥＮＡＮＡ5N7ctgSEol
448Please respect copyright.ＰＥＮＡＮＡiJDfNnGynY
448Please respect copyright.ＰＥＮＡＮＡ5iQPtuHELp
(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質，使自己得以在困局下苟延殘喘。448Please respect copyright.ＰＥＮＡＮＡkVsDNViZMX
448Please respect copyright.ＰＥＮＡＮＡAmb69AHi9Q
448Please respect copyright.ＰＥＮＡＮＡVbnTEdQ3va
情形就如人們債務纏身而又沒有收入抵債的時候，只好變賣自己所持有的資產，化成現金抵償。448Please respect copyright.ＰＥＮＡＮＡwBIsT1KyGZ
448Please respect copyright.ＰＥＮＡＮＡ4nl6DyTmEq
由此可以想像，這是一道治標不治標的方法。448Please respect copyright.ＰＥＮＡＮＡNd5H9Opy0Z
當長期沒有營養流入細胞，而細胞再也沒有多餘物質進行自噬的時候，細胞便會啟動自行滅亡的機制。448Please respect copyright.ＰＥＮＡＮＡoEXGI8eExX
448Please respect copyright.ＰＥＮＡＮＡtJsWe5z4xu
448Please respect copyright.ＰＥＮＡＮＡsOpINy3HCn
(圖3)如果催谷癌細胞不斷進行自噬作用的話，促使它們啟動自行滅亡的機制，那豈不是殺滅它們的一道妙計?448Please respect copyright.ＰＥＮＡＮＡ12YB2epD9G
448Please respect copyright.ＰＥＮＡＮＡ8izn7J0coF
448Please respect copyright.ＰＥＮＡＮＡCQ0R2dvBiq
很遺憾地，各款癌細胞對於自噬作用的依賴及抗性均有所不同，難以就此單一針對自噬作用來消滅癌細胞。448Please respect copyright.ＰＥＮＡＮＡpFKVxHlWmq
448Please respect copyright.ＰＥＮＡＮＡm1DN9NFPFX
暫時較為統一的發現是，大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。448Please respect copyright.ＰＥＮＡＮＡCaaPFeBvQH
448Please respect copyright.ＰＥＮＡＮＡBqH1nV1rNs
在實驗室細胞模型及老鼠實驗中，若果對胰臟癌細胞使用抑制自噬作用的藥物，不但改變它們的新陳代謝，且可減慢癌細胞的生長速度，非常之有潛質成為對抗胰臟癌的其中一手段。448Please respect copyright.ＰＥＮＡＮＡW4I3VxRiQb
448Please respect copyright.ＰＥＮＡＮＡGzbAqJbiLP
448Please respect copyright.ＰＥＮＡＮＡbhMOCvVGp2
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。448Please respect copyright.ＰＥＮＡＮＡBtesyxY0kQ
448Please respect copyright.ＰＥＮＡＮＡ5uPaMsIBxz
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc448Please respect copyright.ＰＥＮＡＮＡdrQQYpdvdo
448Please respect copyright.ＰＥＮＡＮＡQI2X4vmH3g
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。448Please respect copyright.ＰＥＮＡＮＡTQnSzJVmG2
448Please respect copyright.ＰＥＮＡＮＡIPex547Oxp
Link:448Please respect copyright.ＰＥＮＡＮＡhcV05ohVZV
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio448Please respect copyright.ＰＥＮＡＮＡSHJrPtcqwC
448Please respect copyright.ＰＥＮＡＮＡdJ4AHpSvO2
448Please respect copyright.ＰＥＮＡＮＡwBCIpdIRuI
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。448Please respect copyright.ＰＥＮＡＮＡ1GlhHZ1pxE
448Please respect copyright.ＰＥＮＡＮＡe8tqSvFM3Z
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/448Please respect copyright.ＰＥＮＡＮＡbh7ZN5hv6c
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long
1
0
