現今至少有兩間公司的人造抗體(LY/REGN)被緊急認可為武肺的治療方法。363Please respect copyright.PENANACLNnLLMz1L
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但基於這兩種人造抗體需經由血管注射,其間病人需卧床約一小時間,且需求人手密切監察整個過程,實際運行的成本非常高昂,因此未能普及。363Please respect copyright.PENANAdBZP0tKoBI
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更甚的是,有數據顯示當人造抗體經血管注射後,能抵達肺部裡頭的數量少至有少(血液抗體含量比肺部抗體含量高出200-500倍有多),且已知當今的武肺病毒變種能有效躲避兩間公司的人造抗體追捕,使至人造抗體的地位日漸式微。363Please respect copyright.PENANA724Q27Ij1N
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(圖2)武肺病毒最主要的作惡地方是肺部,要解決肺部抗體含量過少的問題,其中一道手段就是從鼻腔注射人造抗體,使其能較易直達肺部。363Please respect copyright.PENANAReqc79PEA0
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從老鼠模型實驗中,可以見到往鼻腔注射人造抗體後,抗體(紅黃色區域)會聚集在鼻腔(N)及肺部(Lu)裡頭。363Please respect copyright.PENANADeVLF4HT0y
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(圖3)至於解決武肺變種的問題,其中一手段就是將五個單一抗體連結成一個個體(五合一),利用「龐大」的身驅阻礙病毒進入細胞。363Please respect copyright.PENANAbctsFJMcE8
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在老鼠實驗中,鼻噴式的五合一抗體能有效阻隔英國及巴西變種等病毒,且有著預防及治療武肺的功效,同時亦沒有對老鼠的體重和明顯特徵做成任何影響。363Please respect copyright.PENANAtBhzz6YXJ2
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若能順利通過人體臨床實驗,定必為世界的安定起來重要的作用。363Please respect copyright.PENANAzFXBcWEHde
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Ref1:https://www.nature.com/articles/s41586-021-03673-2_reference.pdf363Please respect copyright.PENANAC6MoD5gYsr