目前來說,mRNA武肺疫苗在應付疫情上擔當著不可或缺的角色。531Please respect copyright.PENANA2jCE0oz9gG
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儘管如此, mRNA疫苗建立的初心,其實是在於對抗癌症方面之上,純粹是因為武肺爆發才出此變陣。531Please respect copyright.PENANA9ElpZZ0xag
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(圖2)早在1990年,科學家已嘗試分別將mRNA及DNA注射到老鼠的肌肉裡頭,然後再切除部份肌肉來檢驗其注射效果。531Please respect copyright.PENANAxcUzlk0EaH
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(圖3)注射約18小時後,科學家透過檢驗肌肉裡頭的螢光表達量來推斷注射效果。531Please respect copyright.PENANAvx8gO8S1aO
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從圖中可見,若將mRNA或DNA的注射份量提升10倍,其螢光表達量亦會相繼提升10倍有多。531Please respect copyright.PENANAYbaG75QZn3
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這實驗的成功,亦因而奠定了日後mRNA疫苗的發展大方向。531Please respect copyright.PENANAx6NKdiAMsr
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下集我們將會講解 BioNTech究竟在mRNA疫苗上的設計做了甚麼的手腳,使之疫苗在免疫系統的觸發上取得重要的平衡。531Please respect copyright.PENANAwnb0ey95El
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Ref1:https://science.sciencemag.org/content/247/4949/1465/tab-pdf531Please respect copyright.PENANAcR2pZjJobl