肛門塞藥較會常用在兒童或不清醒的病人身上。基於大腸的表面面積非常大,而且鄰近血液循環系統,所以肝門塞藥大多時候均會比口服藥物更有效率進入血液裡頭。804Please respect copyright.PENANAEUyF0ynKGl
804Please respect copyright.PENANARV8K6zoAWx
804Please respect copyright.PENANAJzt4sAu4Qq
只不過最終是以口服還是肛門塞藥服用,請遵照醫生的吩咐及指示。804Please respect copyright.PENANASmi5bPud5s
804Please respect copyright.PENANAPBAmCIeAfd
804Please respect copyright.PENANAIU7Eqjaji7
(圖2)有科學家受腸道鉤蟲啟發,設計出勾狀式藥物,並發表文章匯報成果(Ref1)。804Please respect copyright.PENANAYa8AvREkXK
勾狀式藥物附上蠟質塗層,遇上體溫後便會溶化,並引致金屬制的勾爪抓緊腸道組織。804Please respect copyright.PENANAEXyJ0XDfxP
804Please respect copyright.PENANAQqiXCNmPOW
804Please respect copyright.PENANAbhq2RD5BQP
804Please respect copyright.PENANAzYdKhSMHxv
(圖3)利用儀器以高壓方式將勾狀式藥物送進腸道位置後,藥物便會從插著腸道內的金屬爪管道排出,進入血液循環系統裡頭。804Please respect copyright.PENANATMmjHNWwif
804Please respect copyright.PENANA1weL8Ztmv0
804Please respect copyright.PENANAac6QzUXFTD
804Please respect copyright.PENANA0tW7A4qRr6
(圖4)如圖中所見,紅線為勾狀式裝置包裝藥物肛塞進入老鼠腸道,而黑線為直接將藥物肛塞進入老鼠腸道的結果。804Please respect copyright.PENANAXDJHusQXEU
804Please respect copyright.PENANA2z8mfbVAU2
804Please respect copyright.PENANARasibh3OY1
利用勾狀式裝置包裝的方式送藥,藥物停留在血液的時間明顯有所增長!804Please respect copyright.PENANA0t6AhtMo2y
804Please respect copyright.PENANAynhRwWNbE8
而經過計算後,意欲往70kg成人輸送10mg Ketorolac的話,大概需要4900個1.5mm長的勾狀藥物。804Please respect copyright.PENANAfC6CycqVKi
804Please respect copyright.PENANA7av0jaEUWe
文中的所有研究結果均透過老鼠身上所得,能否套用在人類身上使用為未知之數。804Please respect copyright.PENANABjd6ODHkK2
804Please respect copyright.PENANA9EUMsA5TZB
另一關於腸道送藥的研究,可參閱:https://www.penana.com/article/475900804Please respect copyright.PENANAB8nFc9sVQ4
804Please respect copyright.PENANABV8V150fcd
804Please respect copyright.PENANAmkKzUnyK4K
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。804Please respect copyright.PENANAgkuUcFYEgm
804Please respect copyright.PENANA5CaKOhRwK5
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc804Please respect copyright.PENANAjd3LJu17my
804Please respect copyright.PENANAxJRVG2NtlA
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。804Please respect copyright.PENANAG3YP7KU8Tx
804Please respect copyright.PENANAnWqhAte3RD
Link:804Please respect copyright.PENANAOoCB0PQriF
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio804Please respect copyright.PENANArbRmMIxyuL
804Please respect copyright.PENANAImC60PUWBk
804Please respect copyright.PENANAwsw9Taq3Fr
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。804Please respect copyright.PENANAlR1zUEZdol
804Please respect copyright.PENANASitScVpIlj
https://www.instagram.com/potatopigtongue/804Please respect copyright.PENANAmLL2lnoobY
804Please respect copyright.PENANAEYWO29jJoH
804Please respect copyright.PENANAzkauSUOXeK
804Please respect copyright.PENANAKE1L5F27iO
Ref1:https://advances.sciencemag.org/content/6/44/eabb4133804Please respect copyright.PENANARmrwOCC8zH