癌症研究中,很多時候都會將癌細胞注入在老鼠身內,然後再試驗各種藥物,認證在實驗室細胞中所獲得的結果。489Please respect copyright.PENANATlA8nIQ6Ic
489Please respect copyright.PENANAdXCttOQb9O
489Please respect copyright.PENANAEJZBkv5EA3
除了老鼠、兔、魚、狗、蟲等動物外,受精雞蛋亦是一款常用的實驗模型。489Please respect copyright.PENANAI86rK6XVsy
489Please respect copyright.PENANA4zcIDXqCNQ
(圖2)受精雞蛋中存有氣囊以及充滿血管系統的外膜,提供了一道營養充足的環境。那外膜的名稱為chorioallantoic membrane (CAM) ,因而這款動物模型亦稱之為CAM model。489Please respect copyright.PENANAOb6hEOIKwR
489Please respect copyright.PENANAuLiyHl8H1u
489Please respect copyright.PENANA4xUkdVzEtV
在受精蛋誕下的第15日前,淋巴系統尚未完善建立,不存在免疫衝突問題,因此適合移植人類癌細胞之用。489Please respect copyright.PENANA326oHyzcYP
489Please respect copyright.PENANAnd4EFXBdAr
同時胚胎痛楚接收系統在第15日前未完整建成,若然能在第15日前完成實驗,道德爭議的問題亦相對減低。489Please respect copyright.PENANAYlIlG1dbE7
489Please respect copyright.PENANAN7Eyfu7mMB
(圖3)從圖中可見,癌細胞會在血管上形成腫瘤,同時癌細胞(綠色螢光)會透過血管轉移到雞蛋各部份,甚至聚居到胚胎的肺部及腎臟位置。489Please respect copyright.PENANA1eWiqSCwO7
489Please respect copyright.PENANAOPE9FfKWdP
489Please respect copyright.PENANANGP0FPLL9H
此方法可同時驗證藥物對於癌細胞繁殖及轉移能力的影響,名副其實的一雞兩味。489Please respect copyright.PENANApBd6qLlUus
489Please respect copyright.PENANAsBszqSNMN0
亦有研究嘗試推展把真實病人的癌細胞樣本移植到CAM model,再試用不同藥物在其上,希望藉此能找出一款最為適合醫治該病人的藥物或方法。489Please respect copyright.PENANAXp7kRiuSrC
489Please respect copyright.PENANAtw8SpomNUP
489Please respect copyright.PENANA3V9cuWokN4
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。489Please respect copyright.PENANATVJB6wf3Xy
489Please respect copyright.PENANAR864OW3FeM
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc489Please respect copyright.PENANACRBejA2KjE
489Please respect copyright.PENANAe6GzXwpLaT
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。489Please respect copyright.PENANAf7i3cjcb1P
489Please respect copyright.PENANAMT5GItsr1w
Link:489Please respect copyright.PENANAayZAycvog2
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio489Please respect copyright.PENANAFpcCK4oywi
489Please respect copyright.PENANAUua052sKbR
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。489Please respect copyright.PENANAPbEAorGCbh
489Please respect copyright.PENANAX5VzM8QxQM
https://www.instagram.com/potatopigtongue/489Please respect copyright.PENANAAxfHtXOmo2
489Please respect copyright.PENANAgFemgpSwOx
489Please respect copyright.PENANALzzleYXCWU
Ref1:https://pubmed.ncbi.nlm.nih.gov/23730406/489Please respect copyright.PENANAYsN11webza
Ref2:https://www.sciencedirect.com/science/article/pii/S0925477316300363489Please respect copyright.PENANASdsW5MqRjq