癌症研究中,很多時候都會將癌細胞注入在老鼠身內,然後再試驗各種藥物,認證在實驗室細胞中所獲得的結果。539Please respect copyright.PENANAwSRyaLK4wr539Please respect copyright.PENANA56BNylALqJ
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除了老鼠、兔、魚、狗、蟲等動物外,受精雞蛋亦是一款常用的實驗模型。539Please respect copyright.PENANAYnE7hZxkOb
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(圖2)受精雞蛋中存有氣囊以及充滿血管系統的外膜,提供了一道營養充足的環境。那外膜的名稱為chorioallantoic membrane (CAM) ,因而這款動物模型亦稱之為CAM model。539Please respect copyright.PENANACWb6IfcmEe539Please respect copyright.PENANARdzZh6VAl1
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在受精蛋誕下的第15日前,淋巴系統尚未完善建立,不存在免疫衝突問題,因此適合移植人類癌細胞之用。539Please respect copyright.PENANAdTuepgEvNP
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同時胚胎痛楚接收系統在第15日前未完整建成,若然能在第15日前完成實驗,道德爭議的問題亦相對減低。539Please respect copyright.PENANATCD7gPY1z2
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(圖3)從圖中可見,癌細胞會在血管上形成腫瘤,同時癌細胞(綠色螢光)會透過血管轉移到雞蛋各部份,甚至聚居到胚胎的肺部及腎臟位置。539Please respect copyright.PENANA6CkILZp8vr539Please respect copyright.PENANAs0kMPJUWPt
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此方法可同時驗證藥物對於癌細胞繁殖及轉移能力的影響,名副其實的一雞兩味。539Please respect copyright.PENANAEHb6U9Hyud
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亦有研究嘗試推展把真實病人的癌細胞樣本移植到CAM model,再試用不同藥物在其上,希望藉此能找出一款最為適合醫治該病人的藥物或方法。539Please respect copyright.PENANAEnowe19Ji0
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Ref1:https://pubmed.ncbi.nlm.nih.gov/23730406/539Please respect copyright.PENANAais4cp45hu
Ref2:https://www.sciencedirect.com/science/article/pii/S0925477316300363539Please respect copyright.PENANAQbvm4WOMGs