季節性流感造成全球每年約290,000-650,000人的死亡。731Please respect copyright.PENANAfuDPDDHwAG
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流感病毒接近每年均會出現變種,基於現時並無統一疫苗對抗各品種,所以很多時候在翌年便要轉換對應的疫苗。731Please respect copyright.PENANAyM6KdEYyGm
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(圖2)流感病毒外部、名為HA的部份,將主宰病毒能否進入人體細胞裡頭。731Please respect copyright.PENANA35EQKsa4oA
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流感病毒的變異較常出現在頭部位置(Head),而現時疫苗的設計亦主要針對HA的頭部位置。731Please respect copyright.PENANAANAz8GQ6RF
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其目標是希望人們注射疫苗後,體內會產生對應HA頭部位置的抗體,阻止病毒進入人體細胞繼而作惡。731Please respect copyright.PENANAhAGA3lhj1B
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(圖3)另一方面來想,流感病毒變種就如不同顏色的花朵一樣。731Please respect copyright.PENANAb6DziPplXb
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雖然花朵各有不同,但莖部位置則大同小異。731Please respect copyright.PENANALQL94IyvGr
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(圖4)基於Stalk位置(花朵莖部位置)的變異成數較細,現時科學家正研發針對Stalk位置的疫苗(Ref1),希望可以透過一款疫苗對抗多款流感變種。731Please respect copyright.PENANAN9tGzYUFBD
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這類型的疫苗現時已進入Phase1狀態,人體試驗找來了51名人士,注射疫苗後體內亦得出相應的大量抗體。731Please respect copyright.PENANAWuzIUozN1Y
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而日後所進行的人體試驗,將會能夠獲取資料測量疫苗能否達到預防流感之效。731Please respect copyright.PENANAJ6FtjtJzY6
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若安全性、效率等等均達到合理水平的話,將來不但之可以不用經常轉換疫苗款式,亦能大大減低疫苗與當下流感款式不吻合的機會,皆大歡喜。731Please respect copyright.PENANAOKZtBp4A2y
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。731Please respect copyright.PENANA8KtY1aczOV
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc731Please respect copyright.PENANA2ZA6TRRsW5
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。731Please respect copyright.PENANAksTeD2a1jm
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Link:731Please respect copyright.PENANA8SvQoPQqOj
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio731Please respect copyright.PENANAphDlS90pg4
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。731Please respect copyright.PENANACCpoVvQAIw
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https://www.instagram.com/potatopigtongue/731Please respect copyright.PENANAxeraFFxDYl
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Ref1:https://www.nature.com/articles/s41591-020-1118-7731Please respect copyright.PENANAvLl4tcG49J