注射武肺疫苗的主要目的,就是誘導身體產生對抗武肺病毒的抗體。401Please respect copyright.PENANAkg6XNsUCra
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但身體製造抗體需時,而且免疫系統薄弱的人士亦有可能沒法製造足夠數量的抗體。在這層面上,直接注射人造抗體的話,便能免去這兩道隱憂。401Please respect copyright.PENANApqM9JuGKh1
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(圖2)從圖中所見,檢測者身體含有武肺抗體的話,身體的病毒數量相對上亦會較少,反之亦然。401Please respect copyright.PENANArUIDyPpjL4
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可見病毒數量與體內抗體含量有著反比的關係。401Please respect copyright.PENANAITOz0YITLb
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(圖3)現今有一推斷,體內武肺病毒數量越多的話,出現重症的機會亦會相繼增加。401Please respect copyright.PENANAggAtBSJqkC
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針對這一點,REGN公司進行臨床測試,為武肺患者注射兩款武肺人造抗體401Please respect copyright.PENANAbWXT0HnbmQ
casirivimab (REGN10933) 和imdevimab (REGN10987),401Please respect copyright.PENANAXE59tyXOkc
觀察能否透過注射人造抗體來減低體內病毒的數量(Ref1)。401Please respect copyright.PENANAJCp6gRXvLw
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(圖4)分別往測試者注射安慰劑(灰線)、2g人造抗體(藍線)和8g人造抗體(綠線)後,可以見得到接受人造抗體注射的人士,其病毒在體內的下降速度比注射安慰劑的來得更快。401Please respect copyright.PENANA27813KNTvD
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(圖5)但若然在注射前已被驗出擁有武肺抗體的話,額外的人造抗體注射並不會導致病毒有顯著的加快下跌(右圖);這有可能是體內的抗體本身已足夠應付現況。401Please respect copyright.PENANA0CAYue10LM
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(圖6)值得留意的是,本身病毒數量越多的話,人造抗體所促使的病毒量下跌效果便會越見明顯。401Please respect copyright.PENANAAWV2G3dWH6
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亦即是代表當體外病毒數量超過某一定數量的時候,體內自身的抗體便會未能足以應付現況,而此時候所注射的人造抗體便會派上用場。401Please respect copyright.PENANAlzyK2tIphg
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(圖7)人造抗體注射後的第28日,其濃度亦相對非常穩定,能給予注射人士一道保護時間。401Please respect copyright.PENANASZYFXadUVf
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人造抗體雖能加快病毒下降的速度,但能否預防重症這一方面並未有充份證據支持。401Please respect copyright.PENANAiorxHDrQkU
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而當患者已出現嚴重症狀後,注射人造抗體能否緩和或解決症狀亦是相當成疑。401Please respect copyright.PENANAxTG2yWy5v1
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但無論如何,若然想達到在短時間內減低體內病毒的數量,人造抗體相信是其中一道的選擇。401Please respect copyright.PENANA4bSEzK9fK7
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMoa2035002401Please respect copyright.PENANA1JIS2oZMtY