腸道手術過後,病人的腸道手術位置有機會與鄰近的腸道連結出一層新的組織,此現象名為沾黏(Adhesion)。418Please respect copyright.PENANAMEUOnZGKCq
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這些組織有機會阻塞腸道或釀成腹痛,需要再進行額外的手術剷除它們。418Please respect copyright.PENANAWjovirb6xQ
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(圖2)當腹腔腸道出現傷口時,我們的免疫細胞便會前往傷處協助傷口收復工作。418Please respect copyright.PENANARYvUbSlOVh
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而手術沾黏的形成,相信是因為手術時所做成的傷口過大,激發某部份的免疫細胞為了修復傷口而所組成的不良產物。418Please respect copyright.PENANAtdk95NVQJu
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(圖3)從圖中可見,短短30分鐘便有無數多的免疫細胞前來聚集傷口處。418Please respect copyright.PENANArCPaAVpbE4
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最近科學家們找出了負責這過程的免疫細胞品種,並發現這些免疫細胞是依靠著表面其中一種蛋白質互相連結對方。418Please respect copyright.PENANA3u8Wmdv9XQ
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若果能建立安全的手段短暫性破壞這些蛋白質的互動,將會能夠大大減低手術後所出現的組織沾黏不良效果。418Please respect copyright.PENANASYLAM065GZ
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Ref1:https://www.gastrosurgery.co.uk/intestinal-adhesions-treatment-london/418Please respect copyright.PENANAy9uJwVcj5c
Ref2:https://science.sciencemag.org/content/371/6533/eabe0595418Please respect copyright.PENANA2zGrRhTIO8