此為上集的補充篇:三十秒科學–癌症所導致的體重流失316Please respect copyright.PENANAog29WIBUNd
https://lih.kg/2397914316Please respect copyright.PENANAdf4sDumsFh
316Please respect copyright.PENANAvb6noQOXbN
癌症惡病質(cancer cachexia)泛指因癌症而導致的體重流失,大部份情況下主要是由喪失肌肉所致,並沒法依靠進食來填補其喪失。316Please respect copyright.PENANAOZNOiBcCAl
316Please respect copyright.PENANAX46jKrgvJs
316Please respect copyright.PENANADKzkeKX9WJ
在眾多癌症之中,高達接近70%的胰臟癌病人會出現cancer cachexia,總體重的損失在六個月內可高達25%。316Please respect copyright.PENANABeAuT5oxuS
相反,患上前列腺癌的病人僅只有約10%的人出現cancer cachexia。316Please respect copyright.PENANA3UUpThlz2b
316Please respect copyright.PENANANLBbaFRwCD
316Please respect copyright.PENANAN9I6uxJ3cF
(圖2)病人出現cancer cachexia的話(以體重損失超過10%為指標),其生存的機率亦會因而顯著下降。316Please respect copyright.PENANAhwlEYx2ho5
316Please respect copyright.PENANAsS1MMfCcje
316Please respect copyright.PENANAxtZbMrakRk
正因如此,若能了解其cancer cachexia機制並加以針對的話,將會是抵抗癌症的其中一道手法。316Please respect copyright.PENANAjTYQhON6rd
316Please respect copyright.PENANA5UC17lYjds
316Please respect copyright.PENANAPeS7EBgGcG
(圖3)癌細胞所導致的體重流失,主要是由肌肉喪失所致。316Please respect copyright.PENANAkrOklL4qQA
而當我們的肌肉受到傷害或撕裂的時候,裡頭的幹細胞以及圖中所指的細胞將會出手幫忙製造肌肉,填補其損失。316Please respect copyright.PENANAqaqwX7ro9E
316Please respect copyright.PENANAZZtduFADFP
316Please respect copyright.PENANAFhfksho0xw
316Please respect copyright.PENANAHLMxfp674s
癌細胞的厲害之處就是能夠釋出物質經由血管到達肌肉,誘導肌肉出現受傷情況之餘,並同時阻止肌肉幹細胞進行重生,因而導致肌肉流失情況發生。316Please respect copyright.PENANAC1oH8cCGTw
316Please respect copyright.PENANA6XDHRdKlaY
癌細胞之所以這樣做,其中的一道推論是希望透過破壞肌肉而使血液間的氨基酸(蛋白質)含量增加,然後借助肝臟把這些氨基酸轉變成糖份,再由血液循環系統輸送給自身所用。316Please respect copyright.PENANAXVYokA9dEP
316Please respect copyright.PENANAPhdTkUtVQo
因著胰臟癌病人出現cancer cachexia的機率較高,有不少科學家均就此利用老鼠胰臟癌模型來研究cancer cachexia的機制。316Please respect copyright.PENANAh5rf8lwhFC
316Please respect copyright.PENANAiOKUSrnQJW
至今已至少找出得到,癌細胞所釋出的物質會導致肌肉幹細胞一種名為Pax7的蛋白質含量不斷上升,並因而導致肌肉幹細胞沒法子進行重組肌肉舉動。316Please respect copyright.PENANAeTwZk10pH8
316Please respect copyright.PENANA8WagDyhGxk
316Please respect copyright.PENANAbNvREJ71dp
316Please respect copyright.PENANAU85Ul1l4FR
316Please respect copyright.PENANAjFIqNfQae2
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。316Please respect copyright.PENANAKh77iQI7jl
316Please respect copyright.PENANA4TZc6sKuUh
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc316Please respect copyright.PENANAEdKeCpAZRL
316Please respect copyright.PENANAevFGTkb94a
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。316Please respect copyright.PENANA8M9pyTuV0I
316Please respect copyright.PENANAUH8Xp9Tt3a
Link:316Please respect copyright.PENANAx0k9mJ8O95
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio316Please respect copyright.PENANAQiT5bEQSvA
316Please respect copyright.PENANAdOB1i8gYVk
316Please respect copyright.PENANA3jiROBVWb7
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。316Please respect copyright.PENANAhFErtxwwTj
316Please respect copyright.PENANAJcSBkWfQn2
Ref1:https://www.nature.com/articles/nrdp2017105316Please respect copyright.PENANA2uGwsf3nw0