減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。967Please respect copyright.ＰＥＮＡＮＡbtWiVlBsd0
967Please respect copyright.ＰＥＮＡＮＡXISY90oZRx
967Please respect copyright.ＰＥＮＡＮＡ5sccQzFqzi
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，967Please respect copyright.ＰＥＮＡＮＡGHzwFnUHtX
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。967Please respect copyright.ＰＥＮＡＮＡkeT7iqRP9Z
967Please respect copyright.ＰＥＮＡＮＡgew5RqEVjl
967Please respect copyright.ＰＥＮＡＮＡ1cUC3g3tGp
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。967Please respect copyright.ＰＥＮＡＮＡx6w0LjOEBQ
967Please respect copyright.ＰＥＮＡＮＡbWyedIfvWF
967Please respect copyright.ＰＥＮＡＮＡ1n4GUlssa3
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。967Please respect copyright.ＰＥＮＡＮＡ3EQdKnXnwx
967Please respect copyright.ＰＥＮＡＮＡP58Y5iQ1xB
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。967Please respect copyright.ＰＥＮＡＮＡeX1YDg1UkZ
967Please respect copyright.ＰＥＮＡＮＡJo1QdrsPZ3
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。967Please respect copyright.ＰＥＮＡＮＡvs0ITtAghm
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。967Please respect copyright.ＰＥＮＡＮＡTCFB1vo4jY
967Please respect copyright.ＰＥＮＡＮＡjQFGGyKQjF
967Please respect copyright.ＰＥＮＡＮＡ3wlOj1CMku
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。967Please respect copyright.ＰＥＮＡＮＡfk9Opgpy1n
967Please respect copyright.ＰＥＮＡＮＡ0twLA127Jk
967Please respect copyright.ＰＥＮＡＮＡgP54cNTbqN
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。967Please respect copyright.ＰＥＮＡＮＡNyxOIfSuZr
967Please respect copyright.ＰＥＮＡＮＡbR3oU4jy79
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。967Please respect copyright.ＰＥＮＡＮＡvaYFi0BmmZ
967Please respect copyright.ＰＥＮＡＮＡi0ayMqQX5n
967Please respect copyright.ＰＥＮＡＮＡvd6RgTG599
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。967Please respect copyright.ＰＥＮＡＮＡ5eKhHYonv3
967Please respect copyright.ＰＥＮＡＮＡTxgoXpfgM7
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc967Please respect copyright.ＰＥＮＡＮＡOxeEHkWBiN
967Please respect copyright.ＰＥＮＡＮＡJk03DTvUdg
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。967Please respect copyright.ＰＥＮＡＮＡyMU4GGVeZQ
967Please respect copyright.ＰＥＮＡＮＡOHodrTd6hE
Link:967Please respect copyright.ＰＥＮＡＮＡpOTAkkmQkt
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio967Please respect copyright.ＰＥＮＡＮＡMES2PzyXYn
967Please respect copyright.ＰＥＮＡＮＡZ8ZNzNB4To
967Please respect copyright.ＰＥＮＡＮＡoJFw82Womq
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。967Please respect copyright.ＰＥＮＡＮＡROmz0YGKPh
967Please respect copyright.ＰＥＮＡＮＡXOMmuFQSpk
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/967Please respect copyright.ＰＥＮＡＮＡC9dbxfPkSf
Ref2:https://www.sciencedirect.com/science/article/pii/S2212877821000466967Please respect copyright.ＰＥＮＡＮＡLk2xypdB0C
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/967Please respect copyright.ＰＥＮＡＮＡpbjJgaOpNS
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/967Please respect copyright.ＰＥＮＡＮＡgJNFuCyx5l
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/967Please respect copyright.ＰＥＮＡＮＡed8i7IUJCW
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