減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。936Please respect copyright.ＰＥＮＡＮＡWPj9pBkUeX
936Please respect copyright.ＰＥＮＡＮＡoYpZ0qk8g1
936Please respect copyright.ＰＥＮＡＮＡGgd6XxTPO7
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，936Please respect copyright.ＰＥＮＡＮＡ4MkLgiR29M
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。936Please respect copyright.ＰＥＮＡＮＡGciuhj12nR
936Please respect copyright.ＰＥＮＡＮＡxYSRj0v0CD
936Please respect copyright.ＰＥＮＡＮＡYJUfiEeIcy
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。936Please respect copyright.ＰＥＮＡＮＡ5i1osxN8r8
936Please respect copyright.ＰＥＮＡＮＡnCy3lfHY74
936Please respect copyright.ＰＥＮＡＮＡDzmaYI4nY9
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。936Please respect copyright.ＰＥＮＡＮＡ6fgkyGNXhV
936Please respect copyright.ＰＥＮＡＮＡomxCr0d1aU
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。936Please respect copyright.ＰＥＮＡＮＡFFKriunilH
936Please respect copyright.ＰＥＮＡＮＡP5v0vteHN2
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。936Please respect copyright.ＰＥＮＡＮＡRy9D777Bxo
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。936Please respect copyright.ＰＥＮＡＮＡny0DxeV5xB
936Please respect copyright.ＰＥＮＡＮＡzl2ynzeOgM
936Please respect copyright.ＰＥＮＡＮＡ7vJcAKtyeo
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。936Please respect copyright.ＰＥＮＡＮＡCPRo4RABiI
936Please respect copyright.ＰＥＮＡＮＡHOvZfiGuB0
936Please respect copyright.ＰＥＮＡＮＡgl84opPYAp
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。936Please respect copyright.ＰＥＮＡＮＡv6NyFBNiDh
936Please respect copyright.ＰＥＮＡＮＡnxnfUE4xlJ
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。936Please respect copyright.ＰＥＮＡＮＡsEj0SmK1EB
936Please respect copyright.ＰＥＮＡＮＡrOaFZ4Juk7
936Please respect copyright.ＰＥＮＡＮＡrZv3nOfzo7
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。936Please respect copyright.ＰＥＮＡＮＡVlaDQqwQjK
936Please respect copyright.ＰＥＮＡＮＡYdShm4lWAI
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc936Please respect copyright.ＰＥＮＡＮＡR4CmnHkH0r
936Please respect copyright.ＰＥＮＡＮＡCATo0NaUhU
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。936Please respect copyright.ＰＥＮＡＮＡ51Ee02cGnC
936Please respect copyright.ＰＥＮＡＮＡaPEboHFncS
Link:936Please respect copyright.ＰＥＮＡＮＡvKD9v2bPeS
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio936Please respect copyright.ＰＥＮＡＮＡIivQZGtTmG
936Please respect copyright.ＰＥＮＡＮＡO3q8RxvVEb
936Please respect copyright.ＰＥＮＡＮＡyg9pLbhvg5
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。936Please respect copyright.ＰＥＮＡＮＡEaW3lpA75D
936Please respect copyright.ＰＥＮＡＮＡh2nkid3rZk
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/936Please respect copyright.ＰＥＮＡＮＡL2eXYppbEB
Ref2:https://www.sciencedirect.com/science/article/pii/S2212877821000466936Please respect copyright.ＰＥＮＡＮＡsODS1hN7w4
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/936Please respect copyright.ＰＥＮＡＮＡ1nOlphS2Mh
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/936Please respect copyright.ＰＥＮＡＮＡgbzB2WjzX2
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/936Please respect copyright.ＰＥＮＡＮＡbFwoSc2Pwu
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