當細胞裡頭出現多餘或者已受損毀的物質，又或者是細胞面臨營養不足的情況，細胞便會啟動名為自噬(Autophagy)的機制，依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪，供自己能量或物質所需。453Please respect copyright.ＰＥＮＡＮＡw9RYwePbu9
453Please respect copyright.ＰＥＮＡＮＡGFSVYCwJPO
453Please respect copyright.ＰＥＮＡＮＡu9VWkvEaZm
早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。453Please respect copyright.ＰＥＮＡＮＡ7KTWgvMrii
三十秒科學–癌細胞也會自肥？453Please respect copyright.ＰＥＮＡＮＡNy9r6hDzm4
- 分享自 LIHKG 討論區453Please respect copyright.ＰＥＮＡＮＡjdluy844f1
https://lih.kg/hgfcNS453Please respect copyright.ＰＥＮＡＮＡzkqGYpcJGq
453Please respect copyright.ＰＥＮＡＮＡ5ZSVJ5oOJq
453Please respect copyright.ＰＥＮＡＮＡJdL6DpZ4c4
(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質，使自己得以在困局下苟延殘喘。453Please respect copyright.ＰＥＮＡＮＡpSaCPfsxHu
453Please respect copyright.ＰＥＮＡＮＡU6QyXBcFZw
453Please respect copyright.ＰＥＮＡＮＡH1oBhtf9vG
情形就如人們債務纏身而又沒有收入抵債的時候，只好變賣自己所持有的資產，化成現金抵償。453Please respect copyright.ＰＥＮＡＮＡAhIcLISsEK
453Please respect copyright.ＰＥＮＡＮＡ2kd7ZJTVdc
由此可以想像，這是一道治標不治標的方法。453Please respect copyright.ＰＥＮＡＮＡn2qcCaZdoc
當長期沒有營養流入細胞，而細胞再也沒有多餘物質進行自噬的時候，細胞便會啟動自行滅亡的機制。453Please respect copyright.ＰＥＮＡＮＡmrjCZQAKWl
453Please respect copyright.ＰＥＮＡＮＡpR54eGuQF9
453Please respect copyright.ＰＥＮＡＮＡ5LmEV4bbga
(圖3)如果催谷癌細胞不斷進行自噬作用的話，促使它們啟動自行滅亡的機制，那豈不是殺滅它們的一道妙計?453Please respect copyright.ＰＥＮＡＮＡkPK6A7zJfa
453Please respect copyright.ＰＥＮＡＮＡuFiHbJHjEQ
453Please respect copyright.ＰＥＮＡＮＡS1scx83yaP
很遺憾地，各款癌細胞對於自噬作用的依賴及抗性均有所不同，難以就此單一針對自噬作用來消滅癌細胞。453Please respect copyright.ＰＥＮＡＮＡ9FV6gPM0hl
453Please respect copyright.ＰＥＮＡＮＡ5ixdsv8nts
暫時較為統一的發現是，大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。453Please respect copyright.ＰＥＮＡＮＡ36QwOBkkkg
453Please respect copyright.ＰＥＮＡＮＡYEYXVxxZ0E
在實驗室細胞模型及老鼠實驗中，若果對胰臟癌細胞使用抑制自噬作用的藥物，不但改變它們的新陳代謝，且可減慢癌細胞的生長速度，非常之有潛質成為對抗胰臟癌的其中一手段。453Please respect copyright.ＰＥＮＡＮＡRpLvgxR4ey
453Please respect copyright.ＰＥＮＡＮＡoujuMrbfHh
453Please respect copyright.ＰＥＮＡＮＡEwXAWWGcjk
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。453Please respect copyright.ＰＥＮＡＮＡq5DiBNoMoy
453Please respect copyright.ＰＥＮＡＮＡt2HDxLVs0K
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc453Please respect copyright.ＰＥＮＡＮＡvYHmlzrR68
453Please respect copyright.ＰＥＮＡＮＡ8u3iFV5Qu2
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。453Please respect copyright.ＰＥＮＡＮＡPQOkL5OiHo
453Please respect copyright.ＰＥＮＡＮＡIZuptXTzxD
Link:453Please respect copyright.ＰＥＮＡＮＡLDI1ymfTHB
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio453Please respect copyright.ＰＥＮＡＮＡ7togORrFKj
453Please respect copyright.ＰＥＮＡＮＡOeqTWR0Jo7
453Please respect copyright.ＰＥＮＡＮＡScd35NytiS
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。453Please respect copyright.ＰＥＮＡＮＡWcBiKrTj8H
453Please respect copyright.ＰＥＮＡＮＡNXK9kqIPH9
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/453Please respect copyright.ＰＥＮＡＮＡ1pzudmjH1T
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long
1
0
