癌細胞從原處走到另一地方(轉移,Metastasis),均需透過血液或淋巴系統作交通渠道。547Please respect copyright.PENANAiiHoI5q73s547Please respect copyright.PENANAkb73jdlHmd
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有不少癌細胞轉移到另一器官後會呈「休養」狀態,不迅速繁殖,而是長期潛伏在另一器官內。547Please respect copyright.PENANAue2M8KPIOg
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因此就算沒能檢測得到循環腫瘤細胞的存在,也不百分百等於未來不會出現癌細胞轉移事件。547Please respect copyright.PENANA1pynLCBAmw
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(圖2)科學家分別把人類及老鼠的癌細胞注入到老鼠模型作研究,發現癌細胞發生轉移的機率是與目的地所含的NK cell數量有關係。547Please respect copyright.PENANAGmoKElg8yq547Please respect copyright.PENANAkm69FbU7jx
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目的地所含的NK cell越多,該地方出現癌細胞轉移的機率亦會越低。547Please respect copyright.PENANA5UallTg1Cw
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之所以會出現這情況,除了是NK cell殺死癌細胞這可能性之外,科學家發現NK cell會釋放interferon-γ (IFN-γ)的物質,誘使癌細胞進入休養狀態,不進行自我繁殖。547Please respect copyright.PENANA9ofmlDSK5z
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(圖3)奈何,至少在肝臟裡頭,一種名為Hepatic stellate cells會釋出CXCL12物質,CXCL12會阻礙NK cell的生長速度。547Please respect copyright.PENANARGdvOm9t9d547Please respect copyright.PENANAeLtPH1UfBX
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久而久之,便再也沒有足夠的NK cell抑制癌細胞的生長,而當潛伏在另一器官的癌細胞快速繁殖之時,這亦是轉移(Metastasis)被鑑定發生之時。547Please respect copyright.PENANAspS9swoiGW
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對此,研發藥物或療程確保NK cell長期處於足夠水平,或許是一道避免癌細胞發生轉移的大方向。547Please respect copyright.PENANA9DMoufojIS
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Ref1:https://www.nature.com/articles/s41586-021-03614-z547Please respect copyright.PENANA1gBraktH9J