腸道是人體吸收葡萄糖的主要地方,亦是消化乳糖酵素(Lactase)的聚居地。893Please respect copyright.PENANALEwPmwBHz2
缺乏Lactase的人並不建議進食含有乳糖的產品,否則會釀起肚痾、腹痛、作嘔等症狀,學名為Lactose Intolerance。893Please respect copyright.PENANAF1HGCCpvdY
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同時,腸道亦是寄生蟲的蝸居,飲用不乾淨水的話有機會讓血吸蟲寄生在腸道之中,引起血吸蟲病(Schistosomiasis),為全球第二大僅次於瘧疾(Malaria)的寄生蟲病。893Please respect copyright.PENANAGs7G0VL6mK
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(圖2)近日,有科學家發表文章(Ref1),他們研發出一款口服藥物,主要利用豬隻作為動物模型,證實豬隻吞下藥物後的12分鐘會腸道形成厚膜。893Please respect copyright.PENANAzmal7KeXKT
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此厚膜不會在其他器官上形成,而在24小時後厚膜亦會自然脫落,排出體外。893Please respect copyright.PENANAhAdClw4wHE
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(圖3)根據口服藥物的配方不同,厚膜的特性亦能隨之轉變。893Please respect copyright.PENANA9UPSHKv4wm
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厚膜可配載消化乳糖酵素(Lactase),對比沒有厚膜,能增強20倍酵素的能力,可消除Lactose Intolerance的問題。893Please respect copyright.PENANAb6BO5Uiyiy
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而增強厚膜密度的話,亦可減少腸道吸收葡萄糖七成能力,這特點尤其受益於糖尿病人,能大幅度阻上血糖飄升。893Please respect copyright.PENANAKzSoyDCVAq
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另外,厚膜亦可配載殺寄生蟲藥(Praziquantel),增加藥物滯留在腸道的時間,更有效率殺滅寄生蟲。893Please respect copyright.PENANA8wktwwfIAu
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(圖4)最為振奮的是,此方法在人類腸道組織亦見效,而且藥物對各種實驗室人體細胞亦無呈現有害效果。893Please respect copyright.PENANAxvq35H4CYZ
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老鼠服用藥物28日後,體重血壓等一切正常。893Please respect copyright.PENANADLR5jyXCKz
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若然此藥物能進一步在人類進行試驗的話,確立藥物運作正常及不會帶來任何副作用或安全問題的話,絕對大有潛質會成為治理糖尿病的新一代藥物。893Please respect copyright.PENANAamcNXlduKz
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。893Please respect copyright.PENANAAgMLs82zNt
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc893Please respect copyright.PENANAWYM5qrVDSs
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。893Please respect copyright.PENANA52uEuVjte8
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Link:893Please respect copyright.PENANA80dJMgmDOo
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio893Please respect copyright.PENANAZiznAF2JwA
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。893Please respect copyright.PENANA0lsoDa38Ia
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Ref1:https://stm.sciencemag.org/content/12/558/eabc0441
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