大部份的人體細胞均會藏有油脂。當細胞需要能源的時候,油脂可以在粒線體裡頭分解成為能源。555Please respect copyright.PENANAFGkAruHBtz
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(圖2)有科學家發現(Ref1),當有細菌入侵細胞的時候,細胞的油脂數量會增加,但相應的體積亦會有所縮小。555Please respect copyright.PENANAmAMzcGsJiI
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(圖3)油脂除了能量儲存功用外,亦提供了各種蛋白質聚集的地方。555Please respect copyright.PENANAB3eUBAUcjp
譬如說,PLN5就是一種引領油脂抵達粒線體的蛋白質。555Please respect copyright.PENANAL1eMPgGUTL
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科學家在文中指出,當有細菌入侵細胞的時候,油脂上的PLN5蛋白質就會減少,取而代之會有各種與免疫系統有關的蛋白質黏附在油脂上,並傾向與細菌接觸。555Please respect copyright.PENANAgMihSrq6BN
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箇中油脂上其中一種名為Cathelicidin的蛋白質便有著破壞部份細菌的外壁功效。555Please respect copyright.PENANAkkL465eQwH
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(圖4)隨著油脂用作對付細菌的關係,油脂再也無瑕抵達粒線體作分解能源之用。因此在對抗入侵者期間,細胞亦會因而傾向轉用葡萄糖作為能量來源。555Please respect copyright.PENANAFSpLQs2Amd
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之於如何善用這種知識來研發對抗感染的療法,那將會是科學家們日後的命題。555Please respect copyright.PENANAigKlh3UyI3
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Ref1:https://science.sciencemag.org/content/370/6514/eaay8085555Please respect copyright.PENANAE8fyW464d0