早前新聞亦有廣泛報導有新「器官」tubarial glands的發現,乃為研究人員在替前列腺病人作檢測的時候無意中尋覓出來。840Please respect copyright.PENANAHuV91Ebkq2
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本文會將整個發現的過程深入淺出一番,順帶講及一下關於癌細胞的話題。840Please respect copyright.PENANAlDpGEzWT7b
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部份癌細胞會傾向攝取葡萄糖提供能量及原料,以支撐其生長速度。840Please respect copyright.PENANAADQUXyTAsD
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18F-FDG-PET scans能夠檢查細胞的葡萄糖攝取量,因而被採取為一道癌細胞的檢測工具。840Please respect copyright.PENANADI7BJyPnAH
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但並不是所有癌細胞均會傾向攝取葡萄糖,以前列腺癌為例,他們傾向攝取Glutamine(氨基酸的一種)及Fatty acid,因此18F-FDG-PET scans並不太適用於前列腺癌檢測方面上。840Please respect copyright.PENANA3LfqVhYCwd
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(圖2)而在檢測前列腺癌方面, PMSA-PET scans是其中一種取代18F-FDG-PET scans的方法,原因是前列腺癌擁有較多的PMSA數量,因此在檢測中會被呈現出來。840Please respect copyright.PENANAEx8yKLKjTv
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而負責分泌唾液的唾腺(Salivary gland),在正常運作狀態下,亦會被PMSA-PET scans檢測得到。840Please respect copyright.PENANAc39dBAkg4i
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(圖3)而就在利用PMSA-PET scans檢驗前列腺病人的時候,研究人員發現了一道在書本上沒有記載的區域(藍色箭嘴所示),與已知的唾腺位置並不吻合(Ref2);840Please respect copyright.PENANApHWz7yhN7L
他們足足檢驗了100名病人樣本,所有人均擁有這區域。840Please respect copyright.PENANA1xO8JbDc4O
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(圖4)從一男一女所捐贈的身體解剖中,肉眼亦可見到其結構的存在,而研究人員亦有做實驗證實其結構擁有大量PMSA,與PMSA-PET scans的結果相乎。840Please respect copyright.PENANAWzrxgR4Cuo
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基於其結構在Torus tubarius位置發現,研究人員提出命名這結構為tubarial glands的主張。840Please respect copyright.PENANA7GzsQ8F2J0
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而究竟應該定位tubarial glands為器官、組織、還是人體第四對唾腺,至今還需要尋求醫學界的共識。840Please respect copyright.PENANAbCDLi3Z4zJ
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若然被證實其結構有著唾腺作用的話,那麼日後進行放射治療的人員便要加倍小心不可傷及其結構位置,以免傷害病人正常器官的運作。840Please respect copyright.PENANAhkjHe4tWzN
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Ref1:https://www.siemens-healthineers.com/en-us/news/mso-case-operated-thyroid-carcinoma.html840Please respect copyright.PENANACnoYbFk1RL
Ref2:https://www.sciencedirect.com/science/article/pii/S0167814020308094840Please respect copyright.PENANA2vxwkUfvsS